SGLT
There are six SGLT proteins identified in human, Despite the prominent sequence homology between SGLT1 and SGLT2, they exhibit distinct physiological and biochemical properties. SGLT1 is primarily expressed in intestine, while SGLT2 is highly expressed in the kidney cortex and plays an important role in reabsorption of glucose in kidney. The major substrates of SGLT1 are both glucose and galactose, whereas SGLT2 prefers glucose to galactose. SGLT1 mutations are found in patients with glucose–galactose malabsorption. Mutations of SGLT2 are associated with the genetic disease Familial Renal Glucosuria. The characterizations of other SGLTs are rather preliminary. Interestingly, SGLT3 has no glucose transport activity, but may serve as a glucose sensor in the enteric nervous system. SGLT4 exhibits higher affinity for mannose than glucose and may function as a mannose transporter. SGLT5, which is highly expressed in kidney cortex, also has a substrate preference for mannose. SGLT6, also known as SMIT2 (myoinositol:Na1 symporter), transports inositol instead of glucose.
References
1.Deng D, et al. Protein Sci. 2016;25(3):546–558.
References
1.Deng D, et al. Protein Sci. 2016;25(3):546–558.
GPCR/G Protein
ACAT(3)
Angiotensin Receptor(27)
Antibacterial(471)
Bombesin Receptor(11)
Bradykinin Receptor(18)
Calcium Channel(137)
cAMP(9)
Cannabinoid Receptor(69)
CaSR(17)
CGRP Receptor(14)
Chemokine Receptor(104)
Cholecystokinin Receptor(17)
CRF Receptor(13)
Dopamine Receptor(145)
Endothelin Receptor(20)
FFAR(5)
Galanin Receptor(1)
GHSR(16)
Glucagon Receptor(36)
GPCR19(7)
GPR119(3)
Hedgehog (Hh)(27)
Histamine Receptor(110)
Imidazoline Receptor(1)
Leukotriene Receptor(9)
LHR(1)
LPA Receptor(12)
Lysophospholipid Receptor(13)
mAChR(25)
MCHR(6)
Melanocortin Receptor(22)
Melatonin Receptor(5)
mGluR(11)
Motilin Receptor(4)
Neurokinin Receptor(34)
Neuropeptide Y Receptor(36)
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Orexin Receptor(14)
Other Targets(3)
OXTR(2)
P2Y Receptor(8)
PAR(24)
Platelet-activating Factor Receptor(2)
Prostaglandin Receptor(60)
PTH Receptor(1)
S1P Receptor(22)
SGLT(22)
Somatostatin Receptor(11)
Urotensin Receptor(4)
Vasopressin Receptor(16)
SGLT
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Leachianone A
catalog no : M29179
cas no: 97938-31-3
Leachianone A is a potential antitoxic agent, it shows inhibitory effects on cadmium- Induced cytotoxicity. -
T-1095
catalog no : M28785
cas no: 209746-59-8
T-1095 is an inhibitor of renal glucose reabsorption and the expression of Na+-glucose cotransporters (SGLTs) and facilitative glucose transporter 2 (GLUT2). -
Enavogliflozin
catalog no : M28202
cas no: 1415472-28-4
Enavogliflozin is an orally available small molecule and sodium glucose transporter 2 inhibitor. -
KGA-2727
catalog no : M22939
cas no: 666842-36-0
KGA-2727 is a potent and selective SGLT1 inhibitor, with Kis of 97.4 nM and 43.5 nM for human and rat SGLT1, respectively.?The selectivity ratios (Ki for SGLT2/Ki for SGLT1) of KGA-2727 are 140 (human) and 390 (rat).?KGA-2727 for the treatment of diabete.KGA-2727, which has a pyrazole-O-glucoside structure, as the first selective SGLT1 inhibitor.? -
Quinine HCl Dihydrate
catalog no : M18893
cas no: 6119-47-7
Quinine HCl Dihydrate is a white crystalline K+ channel blocker, used to treat malaria.