Leukotriene Receptor
The leukotriene receptors are activated by the endogenous ligands leukotrienes (LT), synthesized from lipoxygenase metabolism of arachidonic acid. The leukotriene (LT) receptors are G protein-coupled receptors that bind and are activated by the leukotrienes. They include the following proteins:BLT1 (Leukotriene B4 receptor 1) ,BLT2 (Leukotriene B4 receptor 2) ,CysLT1 (Cysteinyl leukotriene receptor 1) ,CysLT2 (Cysteinyl leukotriene receptor 2) .BLT1 had been considered as an important drug target, especially for inflammatory diseases. Here we describe representative reports on animal disease models using BLT1-knockout (BLT1-KO) mice and BLT1 antagonists.BLT2 agonists are attracting interest as new drugs for skin, corneal, and intestinal ulcers.
References
1.Takehiko Yokomizo et al.J Clin Invest. 2018 Jul 2; 128(7): 2691–2701.
References
1.Takehiko Yokomizo et al.J Clin Invest. 2018 Jul 2; 128(7): 2691–2701.
GPCR/G Protein
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Leukotriene Receptor
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Ablukast
catalog no : M27842
cas no: 96566-25-5
Ablukast is a leuktriene receptor antagonist. Ablukast acts as an anti-asthmatic. -
L 674573
catalog no : M27775
cas no: 127481-29-2
L 674573 is an inhibitor of leukotriene biosynthesis. -
LY 255283
catalog no : M22528
cas no: 117690-79-6
LY 255283 is a specific antagonit of leukotriene B4 (LTB4) receptor. -
Nedocromil
catalog no : M15644
cas no: 69049-73-6
Nedocromil (FPL59002) is a mast cell stabilizer, inhibits the degranulation of mast cells, prevents release of histamine and tryptase. -
Amelubant
catalog no : M14191
cas no: 346735-24-8
Amelubant (BIIL284) is a potent, long-acting, orally active leukotriene B4 (LTB4) receptor antagonist.