Angiotensin Receptor
Angiotensin (Ang) II is the effector molecule of the reninangiotensin-aldosterone system. An eight amino acid peptide, Ang II exerts a wide range of actions in the kidney, heart, vascular system, adrenal gland and central nervous systems.Ang II exerts its actions via a family of membrane bound receptors that are widely distributed. Based on ligand binding experiments, two major types of specific Ang II binding sites have been defined and designated AT1 and AT2. Several investigators have succeeded in the molecular cloning of the AT1 receptors from numerous species. The combined results indicate that the Ang II receptor belongs to the super family of seven transmembrane, G-protein coupled receptors.The regulation of the Ang II receptor function is a complex yet physiologically important process. The mechanisms underlying the coupling of AT1 receptor with vasopressive and growth effect of A-II have been well studied, and AT2 receptor stimulation has been related to an increase in cyclic GMP and NO in arterial vascular tissue.
References
1.Sasamura H,et al. Kidney Int. 1994 Dec;46(6):1499-501. 2.White M, et al. Expert Opin Investig Drugs. 2001 Sep;10(9):1687-701.
References
1.Sasamura H,et al. Kidney Int. 1994 Dec;46(6):1499-501. 2.White M, et al. Expert Opin Investig Drugs. 2001 Sep;10(9):1687-701.
GPCR/G Protein
ACAT(3)
Angiotensin Receptor(27)
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Bradykinin Receptor(18)
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Angiotensin Receptor
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Saralasin
catalog no : M30801
cas no: 34273-10-4
Competitive non-selective angiotensin II antagonist. -
Norleual
catalog no : M30627
cas no: 334994-34-2
Angiotensin IV analog. Highly potent HGF/c-MET inhibitor (IC50 = 3 pM). Inhibits HGF-induced MDCK cell proliferation and invasion in vitro. Also AT4 receptor antagonist; disrupts LTP stabilization. Antiangiogenic. -
Brain Natriuretic Peptide (BNP) (1-32), rat
catalog no : M30454
cas no: 133448-20-1
Brain Natriuretic Peptide (BNP) (1-32), rat is a 32 amino acid polypeptide secreted by the ventricles of the heart in response to excessive stretching of heart muscle cells (cardiomyocytes).Brain natriuretic peptide (type B natriuretic peptide) was originally isolated from brain, but is mainly produced in myoendocrine cells of the heart ventricles from which it is released into the circulation. -
Angiotensin II (1-4), human
catalog no : M30308
cas no: 52580-29-7
Angiotensin II is a potent direct vasoconstrictor, causing arteries and veins to constrict, so leading to an increase in blood pressure. Angiotensin also potentiates the release of norepinephrine by a direct action on postganglionic sympathetic fibers. -
C-Type Natriuretic Peptide (1-53), human
catalog no : M30280
cas no: 141294-77-1
CNP, a member of the natriuretic peptide family, was first identified in porcine brain and later found in other mammals as well as non-mammals. Processing of the CNP precursor gives rise to CNP-22 and its N-terminally elongated form, CNP-53. The CNPs share considerable sequence homology with ANP and BNP within the disulfide loop and exert similar pharmacological actions, although with different relative potencies.