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Angiotensin Receptor

Angiotensin (Ang) II is the effector molecule of the reninangiotensin-aldosterone system. An eight amino acid peptide, Ang II exerts a wide range of actions in the kidney, heart, vascular system, adrenal gland and central nervous systems.Ang II exerts its actions via a family of membrane bound receptors that are widely distributed. Based on ligand binding experiments, two major types of specific Ang II binding sites have been defined and designated AT1 and AT2. Several investigators have succeeded in the molecular cloning of the AT1 receptors from numerous species. The combined results indicate that the Ang II receptor belongs to the super family of seven transmembrane, G-protein coupled receptors.The regulation of the Ang II receptor function is a complex yet physiologically important process. The mechanisms underlying the coupling of AT1 receptor with vasopressive and growth effect of A-II have been well studied, and AT2 receptor stimulation has been related to an increase in cyclic GMP and NO in arterial vascular tissue.

References

1.Sasamura H,et al. Kidney Int. 1994 Dec;46(6):1499-501. 2.White M, et al. Expert Opin Investig Drugs. 2001 Sep;10(9):1687-701.

GPCR/G Protein

ACAT(2) Angiotensin Receptor(19) Antibacterial(231) Bombesin Receptor(7) Bradykinin Receptor(3) Calcium Channel(78) cAMP(3) Cannabinoid Receptor(42) CaSR(15) CGRP Receptor(9) Chemokine Receptor(104) Cholecystokinin Receptor(10) CRF Receptor(2) Dopamine Receptor(61) Endothelin Receptor(10) FFAR(5) Galanin Receptor(1) GHSR(7) Glucagon Receptor(11) GPCR19(3) GPR119(3) Hedgehog (Hh)(23) Histamine Receptor(77) Imidazoline Receptor(1) Leukotriene Receptor(6) LHR(1) LPA Receptor(3) Lysophospholipid Receptor(13) mAChR(23) MCHR(2) Melanocortin Receptor(7) Melatonin Receptor(5) mGluR(10) Motilin Receptor(2) Neurokinin Receptor(11) Neuropeptide Y Receptor(1) Neurotensin Receptor(1) Orexin Receptor(11) Other Targets(1) OXTR(2) P2Y Receptor(6) PAR(7) Platelet-activating Factor Receptor(2) Prostaglandin Receptor(28) PTH Receptor(1) S1P Receptor(7) SGLT(18) Somatostatin Receptor(5) Urotensin Receptor(1) Vasopressin Receptor(7)