MCHR
Melanin-concentrating hormone (MCH) is a cyclic peptide, isolated and sequenced originally from salmon pituitary. The rat MCH is 19 amino acids long, two amino acids longer than its salmon counterpart, and is identical to the human MCH, the sequence of which was deduced by cloning. In rodents, MCH is prominently expressed in the perikarya of the lateral hypothalamus and the zona incerta, and projects broadly throughout the central nervous system(CNS). MCHR exhibits several different structures. First, under its original name of somatostatin-like receptor (SLC)-1 or GPR24, it has been described as a 402 amino acid-long human GPCR that was discovered by genomic cloning and delineated by an assigned start codon. In addition to the SLC-1 form of the MCHR, two other MCHR cDNAs were found in a human embryonic brain cDNA library. MCH may function as a neurotransmitter/neuromodulator in a broad array of behavioral responses. MCHR receptor is in fact SLC-1, an orphan G-protein-coupled receptor (GPCR). The SLC-1 GPCR was discovered as an expressed sequence tag exhibiting about 40% homology in its hydrophobic domains to the five somatostatin receptors.SLC-1 reactivity was monitored in three different ways: (1) by intracellular changes in calcium influxes upon coexpression of a Gaq/i3 chimeric protein engineered to force SLC-1 coupling to the phospholipase C pathway; (2) by inhibition of intracellular cAMP accumulation; and (3) by G-protein-gated inwardly rectifying potassium channels (GIRKs) in Xenopus oocytes injected with SLC-1 cRNAs.
References
1.Saito Y, et al. Trends Endocrinol Metab. 2000;11(8):299–303.
References
1.Saito Y, et al. Trends Endocrinol Metab. 2000;11(8):299–303.
GPCR/G Protein
ACAT(3)
Angiotensin Receptor(27)
Antibacterial(471)
Bombesin Receptor(11)
Bradykinin Receptor(18)
Calcium Channel(137)
cAMP(9)
Cannabinoid Receptor(69)
CaSR(17)
CGRP Receptor(14)
Chemokine Receptor(104)
Cholecystokinin Receptor(17)
CRF Receptor(13)
Dopamine Receptor(145)
Endothelin Receptor(20)
FFAR(5)
Galanin Receptor(1)
GHSR(16)
Glucagon Receptor(36)
GPCR19(7)
GPR119(3)
Hedgehog (Hh)(27)
Histamine Receptor(110)
Imidazoline Receptor(1)
Leukotriene Receptor(9)
LHR(1)
LPA Receptor(12)
Lysophospholipid Receptor(13)
mAChR(25)
MCHR(6)
Melanocortin Receptor(22)
Melatonin Receptor(5)
mGluR(11)
Motilin Receptor(4)
Neurokinin Receptor(34)
Neuropeptide Y Receptor(36)
Neurotensin Receptor(8)
Orexin Receptor(14)
Other Targets(3)
OXTR(2)
P2Y Receptor(8)
PAR(24)
Platelet-activating Factor Receptor(2)
Prostaglandin Receptor(60)
PTH Receptor(1)
S1P Receptor(22)
SGLT(22)
Somatostatin Receptor(11)
Urotensin Receptor(4)
Vasopressin Receptor(16)
MCHR
-
[Ala17]-MCH
catalog no : M30637
cas no: 359784-84-2
Potent melanin-concentrating hormone (MCH) receptor agonist (EC50 values are 17 and 54 nM at MCH1 and MCH2 receptors respectively). Displays some selectivity towards MCH1 over MCH2 (Ki values are 0.16 and 34 nM respectively). -
MCH (human, mouse, rat)
catalog no : M22355
cas no: 128315-56-0
Potent endogenous agonist at melanin-concentration hormone (MCH) receptors (IC50 values are 0.3 and 1.5 nM and EC50 values are 3.9 and 0.1 nM at MCH1 and MCH2 receptors respectively). Increases food intake in vivo. -
SNAP 94847 hydrochloride
catalog no : M21140
cas no: 1781934-47-1
SNAP 94847 hydrochloride is a melanin-concentrating hormonereceptor1 (MCHR1) antagonist(Ki= 2.2 nM). -
SNAP-94847
catalog no : M20136
cas no: 487051-12-7
SNAP-94847 is a selective and competitive MCH1 receptor (MCH1-R) antagonist (Ki: 2.2 nM). It has anxiolytic and antidepressant activity and reduces food intake in mice. -
AZD-1979
catalog no : M11025
cas no: 1254035-84-1
A potent, selective melanin concentrating hormone receptor 1 (MCH-R1) antagonist with binding Ki of 12.2 nM.