GHSR
Ghrelin was originally isolated from the stomach mucosa and functions as the ligand of the growth hormone secretagogue receptor (GHSR). Ghrelin functions to modulate hormone secretion, energy balance, gastric acid release, appetite, gastric motility, insulin secretion and the turnover of gastric and intestinal mucosa. The local production of ghrelin and GHSR has been observed in many tissues including the kidney, stomach, small intestine, large intestine, hypothalamus, pituitary gland, endocrine pancreas and placenta. Ghrelin induces cancer cell proliferation through the GHS-R/Ras/PI3K/Akt/mTOR axis. Furthermore, ghrelin also promots oral cancer proliferation via modulation of GLUT1 expression. Ghrelin promotes cell migration and invasion by GHSR/PI3K/Akt signaling pathway that the mechanism is proven to be blocked by the ghrelin receptor antagonist. Furthermore, ghrelin is reported to induce cell migration via regulating GHSR/CaMKII/AMPK/NF-κB signaling pathway. Ghrelin plays an important role in several key processes of cancer progression, including cell proliferation, migration and invasion, the role of ghrelin in promoting or inhibiting cancer progression is still unclear.
References
1.Lin TC, et al. Biochim Biophys Acta Rev Cancer. 2017;1868(1):51–57.
References
1.Lin TC, et al. Biochim Biophys Acta Rev Cancer. 2017;1868(1):51–57.
GPCR/G Protein
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GHSR
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des-Gln14-Ghrelin (rat)
catalog no : M30687
cas no: 293735-04-3
An endogenous ligand for the ghrelin receptor (GHS-R1a), produced by alternative splicing of the rat ghrelin gene. Potently induces Ca2+ release in cells expressing ghrelin receptors (EC50 = 2.4 nM) and stimulates GH release in vivo. -
K-(D-1-Nal)-FwLL-NH2
catalog no : M30655
cas no: 1394288-22-2
High affinity and potent ghrelin receptor inverse agonist (Ki values are 4.9 and 31 nM in COS7 and HEK293T cells, respectively). Blocks ghrelin receptor-mediated Gq- and G13-dependent signaling pathways. -
Human growth hormone-releasing factor
catalog no : M29854
cas no: 83930-13-6
Human growth hormone-releasing factor stimulates GH production and release by binding to the GHRH Receptor (GHRHR) on cells in the anterior pituitary.Growth hormone-releasing hormone is a hormone produced in the hypothalamus. The main role of growth hormone-releasing hormone is to stimulate the pituitary gland to produce and release growth hormone into the bloodstream. -
Capromorelin Tartrate
catalog no : M23880
cas no: 193273-69-7
Capromorelin Tartrate is a potent, orally active growth hormone secretagogue receptor (GHSR) agonist (Ki: 7 nM for hGHS-R1a). -
Pralmorelin acetate 158861-67-7(free base)
catalog no : M22995
cas no: ——
Pralmorelin acetate stimulates growth hormone secretion.Pralmorelin?acetate is an oral active synthetic peptide analogue of MEK.?Pralmorelin?acetate, an auxin releasing peptide/growth hormone secretory receptor agonist, can selectively stimulate ghrelin receptor and cause growth hormone release.?