Hedgehog (Hh)
Hedgehog (Hh) signalling was initially characterised through its role in patterning the Drosophila larval epidermis, where spatially restricted expression of Hh – the single Hh family protein present in flies – maintains expression of the Drosophila Wnt1 orthologue wingless (wg) in neighbouring cells. In vertebrates, the spatially restricted expression of sonic hedgehog (Shh) – the most extensively studied of the vertebrate Hh proteins – in the developing limb bud plays a remarkably similar role, regulating cell proliferation and patterning of the appendages. Shh functions as an axon guidance cue and plays a crucial role in tissue homeostasis as well as in the regenerative response to injury in a number of organs, including the bladder, airway, heart and fin. Vertebrates have two Patched genes (Ptch1 and Ptch2), the products of which play partially redundant roles in Hh reception. Hh proteins are found in many animals, from jellyfish to human. Hh proteins bind to several other type 1 membrane proteins that are required for pathway activation: vertebrate Cdo and Boc and their Drosophila counterparts Ihog and Boi, and the vertebrate-specific Gas1. These co-receptors act semi-redundantly to mediate Hh pathway activation. The expression of Ptc/Ptch and Hhip1 is induced upon Hh pathway activation, creating a negative-feedback loop.
References
1.Lee RT,et al. Development. 2016 Feb 1;143(3):367-72.
References
1.Lee RT,et al. Development. 2016 Feb 1;143(3):367-72.
GPCR/G Protein
ACAT(3)
Angiotensin Receptor(27)
Antibacterial(471)
Bombesin Receptor(11)
Bradykinin Receptor(18)
Calcium Channel(137)
cAMP(9)
Cannabinoid Receptor(69)
CaSR(17)
CGRP Receptor(14)
Chemokine Receptor(104)
Cholecystokinin Receptor(17)
CRF Receptor(13)
Dopamine Receptor(145)
Endothelin Receptor(20)
FFAR(5)
Galanin Receptor(1)
GHSR(16)
Glucagon Receptor(36)
GPCR19(7)
GPR119(3)
Hedgehog (Hh)(27)
Histamine Receptor(110)
Imidazoline Receptor(1)
Leukotriene Receptor(9)
LHR(1)
LPA Receptor(12)
Lysophospholipid Receptor(13)
mAChR(25)
MCHR(6)
Melanocortin Receptor(22)
Melatonin Receptor(5)
mGluR(11)
Motilin Receptor(4)
Neurokinin Receptor(34)
Neuropeptide Y Receptor(36)
Neurotensin Receptor(8)
Orexin Receptor(14)
Other Targets(3)
OXTR(2)
P2Y Receptor(8)
PAR(24)
Platelet-activating Factor Receptor(2)
Prostaglandin Receptor(60)
PTH Receptor(1)
S1P Receptor(22)
SGLT(22)
Somatostatin Receptor(11)
Urotensin Receptor(4)
Vasopressin Receptor(16)
Hedgehog (Hh)
-
SMANT hydrochloride
catalog no : M27712
cas no: 1177600-74-6
SMANT hydrochloride is an antagonist of Smoothened accumulation. -
MRT-10
catalog no : M27665
cas no: 330829-30-6
MRT 10 is a smoothened (Smo) receptor antagonist (an IC50 = 0.5 μM in HEK293 cells transiently expressing mouse Smo). -
GSA-10
catalog no : M27632
cas no: 300833-95-8
GSA-10 is a potent Smoothened (Smo) receptor agonist with an EC50 of 1.2 μM. It acts on Smo to promote the differentiation of pluripotent mesenchymal stem cells into osteoblasts. -
ALLO-2
catalog no : M22837
cas no: 1357350-60-7
ALLO-2 is a Inhibitor of Drug-Resistant Smo Mutant.It?inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM. -
Naftifine hydrochloride
catalog no : M19365
cas no: 65473-14-5
Naftifine Hydrochloride is the hydrochloride salt form of naftifine, an allylamine derivate with synthetic broad-spectrum antifungal activity.