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Imidazoline Receptor

Imidazoline receptors are the primary receptors on which clonidine and other imidazolines act.There are three known subtypes of imidazoline receptors: I1, I2, and I3.The imidazoline receptors have recently been discovered to be involved in central nervous system control of blood pressure (I-1 receptor) and in neuroprotection for cerebral ischemia (I-2 receptor).Much of the antihypertensive action of imidazoline drugs such as clonidine is mediated by the I1 receptor. In addition, I1 receptor activation is used in ophthalmology to reduce intraocular pressure.Preliminary research suggests that I2 receptor agonists may be effective in chronic, but not acute pain, including fibromyalgia.I2 receptor activation has also been shown to decrease body temperature, potentially mediating neuroprotective effects seen in rats.

References

1.Yu A, Frishman WH.Yu A1, Frishman WH.
2.Li, JX (16 March 2017). ""Imidazoline I2 receptors: An update"". Pharmacology & Therapeutics. 178: 48–56.

GPCR/G Protein

ACAT(3) Angiotensin Receptor(16) Antibacterial(421) Bombesin Receptor(11) Bradykinin Receptor(17) Calcium Channel(115) cAMP(9) Cannabinoid Receptor(65) CaSR(8) CGRP Receptor(10) Chemokine Receptor(65) Cholecystokinin Receptor(12) CRF Receptor(11) Dopamine Receptor(123) Endothelin Receptor(14) FFAR(0) Galanin Receptor(0) GHSR(10) Glucagon Receptor(27) GPCR19(7) GPR119(0) Hedgehog (Hh)(26) Histamine Receptor(90) Imidazoline Receptor(0) Leukotriene Receptor(3) LHR(0) LPA Receptor(12) Lysophospholipid Receptor(0) mAChR(3) MCHR(4) Melanocortin Receptor(17) Melatonin Receptor(1) mGluR(2) Motilin Receptor(2) Neurokinin Receptor(28) Neuropeptide Y Receptor(35) Neurotensin Receptor(7) Orexin Receptor(3) Other Targets(3) OXTR(0) P2Y Receptor(2) PAR(20) Platelet-activating Factor Receptor(1) Prostaglandin Receptor(46) PTH Receptor(0) S1P Receptor(22) SGLT(7) Somatostatin Receptor(8) Urotensin Receptor(3) Vasopressin Receptor(11)