Vasopressin Receptor
AVP is synthesized in three hypothalamic nuclei. These are the supraoptic nucleus, the paraventricular nucleus, and the suprachiasmatic nucleus. Neurons in the supraoptic nucleus and magnocellular neurons in the paraventricular nucleus are involved in the response to hypertonicity and volume depletion and send axons to the neurohypophysis for vasopressin secretion. AVP exerts its effects on cells through three G-proteincoupled receptors. The V1a and V1b subtypes are coupled to Gq/11 and activate phospholipase C leading to increases in inositol trisphosphate and diacylglycerol with secondary increases in cell calcium and activation of protein kinase C. The V2 receptor activates the Gs-coupled adenyl cyclase system causing increased intracellular levels of cyclic adenosine monophosphate (cAMP). Within the central nervous system, AVP has a number of cognitive and behavioral effects to include regulation of aggression, social recognition, and certain aspects of pair bonding.
References
1.Palmer BF. Curr Hypertens Rep. 2015;17(1):510.
References
1.Palmer BF. Curr Hypertens Rep. 2015;17(1):510.
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Vasopressin Receptor(16)
Vasopressin Receptor
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(d(CH2)51,Tyr(Me)2,Arg8)-Vasopressin
catalog no : M30829
cas no: 73168-24-8
Selective vasopressin V1A receptor antagonist. Inhibits vasopressin and oxytocin-induced increases in intracellular calcium concentrations in vitro (IC50 values are 5 and 30 nM respectively). Exhibits potent and prolonged antivasopressor activity and induces anxiolytic-like effects in the dorsal, but not ventral, hippocampus in vivo. -
d[Leu4,Lys8]-VP
catalog no : M30782
cas no: 42061-33-6
Selective vasopressin V1B receptor agonist (Ki values are 0.16, 64, 100 and 3800 nM for V1B, oxytocin, V2 and V1A receptors respectively). Displays weak antidiuretic, vasopressor and in vitro oxytocic activities. -
d[Cha4]-AVP
catalog no : M30752
cas no: 500170-27-4
Potent and selective human vasopressin V1B receptor agonist (Ki values are 1.2, 151, 240 and 750 nM for V1B, V1A, Oxytocin and V2 receptors respectively). Stimulates ACTH and corticosterone secretion and exhibits negligible vasopressor activity in vivo. -
Felypressin acetate
catalog no : M27820
cas no: 914453-97-7
Felypressin acetate is an agonist of vasopressin 1 and acts on all arginine vasopressin receptors 1AS. Felypressin acetate can be used in dental procedures. -
Terlipressin Acetate
catalog no : M23860
cas no: 1884420-36-3
Terlipressin, a highly selective vasopressin V1 receptor agonist, on oxygen and glucose deprivation/re-oxygenation (OGD/R)-induced damage in intestinal epithelial cells (IEC-6).