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Vasopressin Receptor

AVP is synthesized in three hypothalamic nuclei. These are the supraoptic nucleus, the paraventricular nucleus, and the suprachiasmatic nucleus. Neurons in the supraoptic nucleus and magnocellular neurons in the paraventricular nucleus are involved in the response to hypertonicity and volume depletion and send axons to the neurohypophysis for vasopressin secretion. AVP exerts its effects on cells through three G-proteincoupled receptors. The V1a and V1b subtypes are coupled to Gq/11 and activate phospholipase C leading to increases in inositol trisphosphate and diacylglycerol with secondary increases in cell calcium and activation of protein kinase C. The V2 receptor activates the Gs-coupled adenyl cyclase system causing increased intracellular levels of cyclic adenosine monophosphate (cAMP). Within the central nervous system, AVP has a number of cognitive and behavioral effects to include regulation of aggression, social recognition, and certain aspects of pair bonding.

References

1.Palmer BF. Curr Hypertens Rep. 2015;17(1):510.

GPCR/G Protein

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