HBV
Chronic HBV infection can lead to advanced liver disease, including cirrhosis and hepatocellular carcinoma. Hepatitis B is viewed as a specific immunity-mediated liver disease. Control of covalently closed circular DNA (cccDNA) amplification is an important feature necessary for the ability of hepadnaviruses to persistently infect cells, without cytopathic effects. The high level of viral replication and cccDNA copy number induce cytopathic changes in both cell culture and the livers of infected animals. HBV replication may also disturb intracellular organelles, causing ER stress and alteration of mitochondrial function and increased replication may lead to depletion of cellular molecular resources like phospholipids that are needed for synthesis of cellular membrane, lipoproteins, and HBV sub and full viral particles. Liver injury can be caused not only by high levels of viral replication in infected hepatocytes, but also by the accumulation of the viral proteins in the absence of HBV replication in hepatocytes. Accumulation of viral proteins does occur in livers of patients with chronic HBV infection.
References
1.Zhang YY and Hu KQ. J Med Virol. 2015;87(12):1989–1999.
References
1.Zhang YY and Hu KQ. J Med Virol. 2015;87(12):1989–1999.
Microbiology/Virology
HBV
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Hepatitis B Virus Core 128-140
catalog no : M30219
cas no: 160015-13-4
The hepatitis B virus (HBV) core protein has been found in the nucleus, the cytoplasm, or both of HBV-infected hepatocytes. nuclear localization of the HBV core protein is negatively regulated by phosphorylation during the cell cycle. -
Inarigivir ammonium
catalog no : M28733
cas no: 2172788-92-8
Inarigivir ammonium is a dinucleotide antiviral compound that significantly reduces HBV DNA in transgenic mice expressing hepatitis B virus. Inarigivir is an agonist of retinoic acid-inducible gene-I (RIG-I) that activates intracellular innate immunity. -
Pradefovir
catalog no : M27916
cas no: 625095-60-5
Pradefovir is a reverse transcriptase inhibitor potentially for treatment of chronic HBV infection. -
DVR-01
catalog no : M27873
cas no: 330461-34-2
DVR-01 is an HBV capsid inhibitor and can be used in studies about the treatment of Hepatitis B virus (HBV) infection and related conditions. -
Vebicorvir
catalog no : M23939
cas no: 2090064-66-5
Vebicorvir is a first-generation hepatitis B virus (HBV) core protein inhibitor, has demonstrated effective antiviral activity.