CMV
Human cytomegalovirus (HCMV) infects most individuals in the world, usually without producing overt symptoms. The broad cellular tropism of HCMV likely contributes to the diverse number of pathologies associated with infection.The deletion of glycoprotein B (gB) renders HCMV incapable of entering cells unless a chemical fusogen (ie polyethylene glycol) is added. HCMV gB has been shown to engage with a number of cellular receptors, including EGF-R, PDGF-Rα, tetherin and integrins (α2β1, α6β1 and αvβ3). Synthesis of a protein on a ribosome (RIB) is digested in the proteasome (PRO), transport of peptides into the endoplasmic reticulum (ER) by the transporter associated with antigenic peptides (TAP) and display, together with class I HLA molecules, at the plasma membrane. HCMV proteins pp65, UL97, US3, US6, US2 and US11 reduce display of mature class I complexes. HCMV proteins UL18 and UL40 present decoy signals to prevent immune attack. HCMV proteins UL16, UL141, UL142 plus micro-RNA UL112-1 block the display of stress ligands, which would otherwise precipitate immune attack.
References
1.Griffiths P,et al. J Pathol. 2015 Jan;235(2):288-97.
References
1.Griffiths P,et al. J Pathol. 2015 Jan;235(2):288-97.
Microbiology/Virology
CMV
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CEF20
catalog no : M30386
cas no: 153045-21-7
CEF20, a CEF control peptide pool, is an HLA-A*0201-restricted epitope from cytomegalovirus pp65 (495-503). -
Brincidofovir
catalog no : M14523
cas no: 444805-28-1
Brincidofovir (CMX 001;Cidofovir HDP) is a lipid conjugate of the acyclic nucleotide phosphonate. -
CFI02
catalog no : M13838
cas no: 273735-28-7
CFI02 (CFI-02) is a specific inhibitor of human cytomegalovirus (HCMV) glycoprotein B-mediated fusion with IC50 of 40 nM against laboratory adapted HCMV strain AD169. -
Tomeglovir
catalog no : M13667
cas no: 233254-24-5
Tomeglovir (BAY 384766) is a potent, highly selective, nonnucleoside inhibitor of cytomegalovirus (CMV) replication. -
GW 275175X
catalog no : M13479
cas no: 217950-62-4
GW 275175X is a derivative of BDCRB that displays anti-HCMV activity by inhibition of viral DNA maturation.