Arenavirus
The Arenaviridae family consists of a unique Arenavirus genus that currently contains 22 recognized virus species. Arenaviruses are enveloped single-stranded RNA viruses, with a genome consisting of two RNA segments, designated large (L) and small (S). Arenavirus species and rodent species are strongly associated in a specific manner, suggestive of a possible co-evolutionary process. Arenaviruses infect a variety of rodent hosts in which they are often nonpathogenic, whereas several are highly pathogenic for humans, resulting in severe hemorrhagic or neurological syndromes in that accidental host. Since their discovery in the early 1930s, new arenaviruses have been discovered and/or have emerged as human pathogens. Prevention of arenaviral disease consists of interrupting the transmission of virus from rodents to humans, from humans to humans, and from infected specimens to laboratory personnel.
References
1.Gonzalez JP,et al. Curr Top Microbiol Immunol. 2007;315:253-88.
References
1.Gonzalez JP,et al. Curr Top Microbiol Immunol. 2007;315:253-88.
Microbiology/Virology
Arenavirus
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LCMV gp33-41
catalog no : M30456
cas no: 151705-84-9
LCMV gp33-41, the carboxyl-extended 11-aa-long peptide, is an lymphocytic choriomeningitis virus sequence restricted by MHC class I H-2Db molecules and presented to cytotoxic T lymphocytes.This is the H-2Db restricted epitope derived from the lymphocytic choreomeningitis virus (LCMV) glycoprotein gp 33; residues 33 to 41. -
GP(33-41)
catalog no : M30450
cas no: 161928-86-5
GP(33-41), a 9-aa-long peptide, is the optimal sequence of the GP1 epitope of lymphocytic choriomeningitis virus, and can upregulate H-2Db molecules at the RMA-S (Db Kb) cell surface with a SC50 of 344 nM. GP33-41 Epitopeis a strong agonist of CD8 T cells from P14 TCR-transgenic mice. -
Glycoprotein 276-286
catalog no : M30339
cas no: 160543-97-5
Known Db-restricted peptide of lymphocytic choriomeningitis virus (LCMV). -
Nucleoprotein 396-404
catalog no : M29777
cas no: 158475-79-7
Nucleoprotein (396-404) is the 396 to 404 fragment of lymphocytic choriomeningitis virus (LCMV). Nucleoprotein (396-404) is the H-2D(b)-restricted immunodominant epitope and can be used as a molecular model of viral antigen. -
LASV inhibitor 3.3
catalog no : M15014
cas no: 554438-52-7
LASV inhibitor 3.3 (LAMP1 inhibitor 3.3) is a specific inhibitor of Lassa fever virus (LASV, IC50=1.8 uM).