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HSP
Based on molecular weight, HSPs are classified into several families, including HSP110, HSP90, HSP70, HSP60, and small HSPs, such as HSP40 and ubiquitin. HSPs are among the most conserved cellular proteins and function as molecular chaperones. They are located in the cytoplasm and in several organelles, where they act in the stabilization of proteins, besides also being mediators of the inflammatory response when present in the extracellular environment. In this regard, HSPs have been investigated in the context of several inflammatory conditions, such as diabetes, arthritis, cancer, and sepsis. HSPs regulate the folding, unfolding, solubilization, transport, biosynthesis, and assembly of cellular proteins. What was commonly seen was a role for HSPs in the reduction of proinflammatory cytokines, inhibition of NFκB, reduction in organ damage, and increased survival.
References
1.Vulczak A,et al. Int J Mol Sci. 2019 Aug 30;20(17).
References
1.Vulczak A,et al. Int J Mol Sci. 2019 Aug 30;20(17).
Cytoskeleton/Cell Adhesion Molecules
HSP
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H2-Gamendazole
catalog no : M36435
cas no: 877768-84-8
H2-Gamendazole is a novel compound for spermatogenesis inhibition and cancer therapy as an inhibitor of heat shock proteins and/or elongation factor 1 alpha, and is an Hsp90 regulator.
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PU-H71 HCl
catalog no : M36291
cas no: 2095432-24-7
PU-H71 HCl (Zelavespib HCl) is a novel Hsp90 inhibitor, a novel purine-based analog, and a radiosensitizer that may be a promising agent for CIRT.
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GRP78-IN-3
catalog no : M36059
cas no: 2707510-30-1
GRP78-IN-3, a potent small-molecule-competitive inhibitor of Hsp70 substrate binding and is a selective Grp78 (HSPA5) inhibitor with an IC50 of 0.59 μM.
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AT-533
catalog no : M36016
cas no: 908112-37-8
AT-533 is a potent inhibitor of Hsp90 and HSV. AT-533 blocks the HIF-1α/VEGF/VEGFR-2 signaling pathway, leading to suppress tumor growth and angiogenesis.
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IPI-493
catalog no : M34626
cas no: 64202-81-9
IPI-493 (17-amino17demethoxy) is a novel HSP90 inhibitor with antitumor activity.