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Dynamin
Dynamin was originally identified as a GTPase that co-purified with brain microtubules. Mammalian genomes contain three dynamin genes16. The proteins encoded by these genes share the same domain organization and 80% overall homology, but they have distinct expression patterns. Dynamin is localized at sites of endocytosis. It is also found at actin meshworks nucleated by the actin-related protein 2/3 (ARP2/3) complex, such as membrane ruffles, podosomes and invadopodia, and at actin pedestals induced by pathogenic bacteria (such as enteropathogenic Escherichia coli (EPEC)). Other dynamin-like proteins (DLPs), including atlastin, dynamin-related protein 1 (DRP1), optic atrophy 1 homologue (OPA1) and mitofusin, localize to sites of intracellular membrane fission and fusion in the endoplasmic reticulum (ER), mitochondria and peroxisomes.
References
1.Ferguson SM,et al. Nat Rev Mol Cell Biol. 2012 Jan 11;13(2):75-88.
References
1.Ferguson SM,et al. Nat Rev Mol Cell Biol. 2012 Jan 11;13(2):75-88.
Cytoskeleton/Cell Adhesion Molecules
Dynamin
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Dynamin IN-2
catalog no : M35809
cas no: 1345853-49-7
Dynamin IN-2 (compound 43) is a Wiskostatin analogue. Dynamin IN-2 is a potent dynamin inhibitor (dynamin I GTPase, IC50= 1.0 μM). Dynamin IN-2 blocks clathrin mediated endocytosis (CME) (IC50= 9.5 μM).
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Dynapyrazole A
catalog no : M34768
cas no: 2226517-75-3
Dynapyrazole A is a specific inhibitor of microtubule dynamin with IC50s of 2.3 and 2.6 μM for dynein 1 and dynein 2-dependent microtubule gliding, and it inhibits Hedgehog signaling with an IC50 of 1.9 μM.
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Dynamin inhibitory peptide, myristoylated TFA
catalog no : M30697
cas no: 251634-22-7
Cell-permeable version of dynamin inhibitory peptide, an inhibitor of the GTPase dynamin that competitively blocks binding of dynamin to amphiphysin, preventing endocytosis. Reduces NMDA receptor internalization.
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Tetradecyltrimethylammonium bromide
catalog no : M27656
cas no: 1119-97-7
MitMAB is a Dynamin GTPase activity inhibitor and a cationic surfactant with asymmetrical structure.
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Trimethyloctadecylammonium bromide
catalog no : M22957
cas no: 1120-02-1
Trimethyloctadecylammonium bromide is an inhibitor of Dynamin I(IC50 : 1.9 μM) and also inhibits Dynamin Ⅱ.