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Kinesin
Kinesin is eukaryotic-conserved motor proteins that move along MTs with ATP hydrolysis. Each kinesin has a motor domain, which converts the energy ATP hydrolysis into mechanical work and which defines a protein as a kinesin.Kinesin plays an essential role in vesicle and organelle transport. It transfers vesicles to the presynaptic axonal regions in order for the mediation of synaptic transmission to occur.The importance of kinesin is underscored by the serious medical consequences, such as diseases like Parkinson’s, Alzheimer’s and Huntington’s, which appear to implicate kinesin’s interactions with disease-associated proteins.
References
1.Takahiro Hamada, in International Review of Cell and Molecular Biology, 2014
References
1.Takahiro Hamada, in International Review of Cell and Molecular Biology, 2014
Cytoskeleton/Cell Adhesion Molecules
Kinesin
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UMK57
catalog no : M34457
cas no: 342595-74-8
UMK57 is a CENP-Ei and MCAK enhancer, selectively promoting k-MT attachment error correction to inhibit chromosome missegregation of small molecule compounds, and can improve chromosome separation conservation by disrupting the stability of kinetosomal microtubule (k-MT) attachment during mitosis.
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Kif15-IN-2
catalog no : M32983
cas no: 672926-33-9
Kif15-IN-2 is a kinesin Kif15 inhibitor with potential anticancer activity and can be used in prostate cancer research.
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Paprotrain
catalog no : M26357
cas no: 57046-73-8
Paprotrain inhibits the ATPase activity of MKLP-2 with an IC50 of 1.35 μM and a Ki of 3.36 μM.
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Eg5 Inhibitor V, trans-24
catalog no : M26190
cas no: 869304-55-2
Eg5 Inhibitor V, trans-24 is a specific and potent Eg5 agonist inhibitor that can be used in cancer research with an IC50 value of 0.65 uM.
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Mps1-IN-3
catalog no : M23708
cas no: 1609584-72-6
Mps1-IN-3 is an effective and selective inhibitor of MPS1 kinase (IC50: 50 nM).