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GRP78-IN-3
CAS No. 2707510-30-1
GRP78-IN-3( —— )
Catalog No. M36059 CAS No. 2707510-30-1
GRP78-IN-3, a potent small-molecule-competitive inhibitor of Hsp70 substrate binding and is a selective Grp78 (HSPA5) inhibitor with an IC50 of 0.59 μM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 67 | In Stock |
|
| 5MG | 100 | In Stock |
|
| 10MG | 155 | In Stock |
|
| 25MG | 288 | In Stock |
|
| 50MG | 457 | In Stock |
|
| 100MG | 732 | In Stock |
|
| 500MG | 1467 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameGRP78-IN-3
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NoteResearch use only, not for human use.
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Brief DescriptionGRP78-IN-3, a potent small-molecule-competitive inhibitor of Hsp70 substrate binding and is a selective Grp78 (HSPA5) inhibitor with an IC50 of 0.59 μM.
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DescriptionGRP78-IN-3 is a selective Grp78 (HSPA5) inhibitor with an IC50 of 0.59 μM. GRP78-IN-3 is 7-fold selective for HspA5 compared to HspA9 (IC50 of 4.3 μM) and >20-fold selective for HspA5 compared to HspA2 (IC50 of 13.9 μM).
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In VitroGRP78-IN-3 (compound 8) is a potent small-molecule-competitive inhibitor of Hsp70 substrate binding. GRP78-IN-3 (0.1-100 μM) shows more potent inhibition efffects in a spheroid tumor model (U251 glioblastoma cells and H520 lung cancer cells).
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In Vivo——
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Synonyms——
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PathwayCytoskeleton/Cell Adhesion Molecules
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TargetHSP
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RecptorHSP
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Research Area——
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Indication——
Chemical Information
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CAS Number2707510-30-1
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Formula Weight342.42
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Molecular FormulaC17H18N4O2S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 5 mg/mL (14.60 mM; Ultrasonic )
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SMILESC(N[C@H](C(NC1=NC=CS1)=O)[C@H](C)C)(=O)C2=CC=3C(N2)=CC=CC3
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Andrew J Ambrose, et al. Discovery and Development of a Selective Inhibitor of the ER Resident Chaperone Grp78. J Med Chem. 2022 Dec 14.?
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