WZ8040 ( WZ8040; WZ8040; WZ 8040 )

Catalog No. M17197 CAS No. 1214265-57-2

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

WZ8040
Note

Research use only, not for human use.
Brief Description

WZ8040 is a novel mutant-selective irreversible EGFRT790M inhibitor, does not inhibit ERBB2 phosphorylation (T798I).
Description

WZ8040 is a novel mutant-selective irreversible EGFRT790M inhibitor with potential anticancer activity. WZ8040 is about 30-fold more potent against EGFR T790M, and up to 100-fold less potent against wild-type EGFR, than other quinazoline-based EGFR inhibitors such as CL-387785 and HKI-272. WZ-8040 may be clinically more effective and better tolerated than quinazoline-based inhibitors.
Synonyms

WZ8040; WZ8040; WZ 8040
Pathway

Cytoskeleton/Cell Adhesion Molecules
Target

Kinesin
Recptor

EGFR (T790M)
Research Area

Cancer
Indication

——

CAS Number

1214265-57-2
Formula Weight

481.01
Molecular Formula

C24H25ClN6OS
Purity

98%
Solubility

——
SMILES

CN1CCN(CC1)C1=CC=C(NC2=NC=C(Cl)C(SC3=CC(NC(=O)C=C)=CC=C3)=N2)C=C1
Chemical Name

N-(3-((5-chloro-2-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)thio)phenyl)acrylamide

1. Zhou W, et al. Nature, 2009, 462(7276), 1070-1074.

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