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Dimethylenastron

CAS No. 863774-58-7

Dimethylenastron ( Dimethylenastron )

Catalog No. M16256 CAS No. 863774-58-7

A small molecule inhibitor of the mitotic kinesin Eg5; inhibits endothelial cell proliferation and migration in vitro.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Dimethylenastron
  • Note
    Research use only, not for human use.
  • Brief Description
    A small molecule inhibitor of the mitotic kinesin Eg5; inhibits endothelial cell proliferation and migration in vitro.
  • Description
    A small molecule inhibitor of the mitotic kinesin Eg5; inhibits endothelial cell proliferation and migration in vitro; exhibits a shorter mitotic arrest, bipolar or multipolar karyokinesis, followed by apoptosis of the daughter cells in dimethylenastron-treated tetraploid cells.
  • Synonyms
    Dimethylenastron
  • Pathway
    Cytoskeleton/Cell Adhesion Molecules
  • Target
    Kinesin
  • Recptor
    Eg5
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    863774-58-7
  • Formula Weight
    302.39
  • Molecular Formula
    C16H18N2O2S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 31 mg/mL
  • SMILES
    O=C1C2=C(NC(NC2C3=CC=CC(O)=C3)=S)CC(C)(C)C1
  • Chemical Name
    5(1H)-Quinazolinone, 2,3,4,6,7,8-hexahydro-4-(3-hydroxyphenyl)-7,7-dimethyl-2-thioxo-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Rello-Varona S, et al. Cell Cycle. 2009 Apr 1;8(7):1030-5.
2. Exertier P, et al. Oncotarget. 2013 Dec;4(12):2302-16.
3. Kaan HY, et al. J Med Chem. 2010 Aug 12;53(15):5676-83.
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