KSP-IA

Research use only, not for human use.

A potent, specific, allosteric and cell-active inhibitor of KSP with IC50 of 11 nM; has no ihibitory activity toward other kinesins.

A potent, specific, allosteric and cell-active inhibitor of KSP with IC50 of 11 nM; has no ihibitory activity toward other kinesins, includin CENP-E, MKLP-1, KIF-3A, and uKHC (IC50>50 uM); induces the formation of monoastral spindles, causes mitotic arrest in a dose-dependent manner (EC50=30 nM) in A2780 ovarian carcinoma cells; sustained KSP inhibition activates the proapoptotic protein, Bax, and both activation of the spindle checkpoint and subsequent mitotic slippage are required for Bax activation.

KSP-IA; KSP IA; KSPIA

Cytoskeleton/Cell Adhesion Molecules

Kinesin

Kinesin

——

——

639074-49-0

356.42

C21H22F2N2O

>98% (HPLC)

——

CC(C)[C@H](N)C(N1[C@H](C2=CC=CC=C2)C=C(C3=CC(F)=CC=C3F)C1)=O

(S)-2-amino-1-((S)-4-(2,5-difluorophenyl)-2-phenyl-2,5-dihydro-1H-pyrrol-1-yl)-3-methylbutan-1-one

(-20℃)

With Ice Pack

≥ 2 years