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K-858
CAS No. 72926-24-0
K-858 ( K-858;K 858 )
Catalog No. M15789 CAS No. 72926-24-0
A potent, selective inhibitor of mitotic kinesin Eg5 ATPase activity with IC50 of 1.3 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 35 | In Stock |
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| 10MG | 65 | In Stock |
|
| 25MG | 143 | In Stock |
|
| 50MG | 259 | In Stock |
|
| 100MG | 462 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameK-858
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective inhibitor of mitotic kinesin Eg5 ATPase activity with IC50 of 1.3 uM.
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DescriptionA potent, selective inhibitor of mitotic kinesin Eg5 ATPase activity with IC50 of 1.3 uM; displays >150-fold more selective for Eg5 than other members of the kinesin superfamily; induces mitotic arrest, apoptosis, and cell growth inhibition through the activation of the Mad2-mediated spindle checkpoint, and has no effect on microtubule polymerization; exhibits potent antitumor activity in xenograft models of cancer, and induces the accumulation of mitotic cells with monopolar spindles in tumor tissues.Breast Cancer Preclinical
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SynonymsK-858;K 858
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PathwayCytoskeleton/Cell Adhesion Molecules
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TargetKinesin
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RecptorEg5ATPase
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Research AreaCancer
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IndicationBreast Cancer
Chemical Information
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CAS Number72926-24-0
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Formula Weight277.34
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Molecular FormulaC13H15N3O2S
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESCC(NC1=NN(C(C)=O)C(C2=CC=CC=C2)(C)S1)=O
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Chemical NameAcetamide, N-(4-acetyl-4,5-dihydro-5-methyl-5-phenyl-1,3,4-thiadiazol-2-yl)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Nakai R, et al. Cancer Res. 2009 May 1;69(9):3901-9.
2. De Iuliis F, et al. Invest New Drugs. 2016 Aug;34(4):399-406.
3. De Monte C, et al. Eur J Med Chem. 2015 Nov 13;105:245-62.
2. De Iuliis F, et al. Invest New Drugs. 2016 Aug;34(4):399-406.
3. De Monte C, et al. Eur J Med Chem. 2015 Nov 13;105:245-62.
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