Cart
sales@molnova.com
SR31527
CAS No. 311814-78-5
SR31527 ( SR 31527;SR-31527 )
Catalog No. M13997 CAS No. 311814-78-5
SR31527 is a novel allosteric Kinesin-like protein KIFC1 inhibitor that inhibits microtubule-stimulated KIFC1 ATPase activity with IC50 of 6.6 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 396 | Get Quote |
|
| 10MG | 594 | Get Quote |
|
| 25MG | 1035 | Get Quote |
|
| 50MG | 1584 | Get Quote |
|
| 100MG | 2448 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameSR31527
-
NoteResearch use only, not for human use.
-
Brief DescriptionSR31527 is a novel allosteric Kinesin-like protein KIFC1 inhibitor that inhibits microtubule-stimulated KIFC1 ATPase activity with IC50 of 6.6 uM.
-
DescriptionSR31527 is a novel allosteric Kinesin-like protein KIFC1 inhibitor that inhibits microtubule-stimulated KIFC1 ATPase activity with IC50 of 6.6 uM, binds directly to KIFC1 with Kd of 25.4 nM; prevents bipolar clustering of extra centrosomes in TNBC cells and significantly reducesTNBC cell colony formation and viability (MDA-MB-231, BT549 and MDA-MB-435s cells IC50=20-30 uM), with less toxicity to normal fibroblasts.
-
SynonymsSR 31527;SR-31527
-
PathwayCytoskeleton/Cell Adhesion Molecules
-
TargetKinesin
-
RecptorKinesin
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number311814-78-5
-
Formula Weight319.81
-
Molecular FormulaC15H14ClN3OS
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESCOC1=CC=C(C2=[N+](C3=CC=CC=C3)SC(N)=N2)C=C1.[Cl-]
-
Chemical Name5-amino-3-(4-methoxyphenyl)-2-phenyl-1,2,4-thiadiazol-2-ium chloride
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Zhang W, et al. Biochem J. 2016 Apr 15;473(8):1027-35.
2. Yukawa M, et al. Fungal Genet Biol. 2018 Apr 21;116:33-41.
2. Yukawa M, et al. Fungal Genet Biol. 2018 Apr 21;116:33-41.
molnova catalog
related products
-
S-Trityl-L-cysteine
S-Trityl-L-cysteine (NSC 83265) is a potent, cell-permeable, selective inhibitor of mitotic kinesin Eg5, inhibits basal ATPase activity (IC50=1 mM) and microtubule-activated ATPase activity of Eg5 (IC50=140 nM).
-
Ispinesib
A potent, selective, cell-permeable, allosteric inhibitor of Eg5 (mitotic kinesin KSP) with Ki of 2.3 nM.
-
WZ8040
WZ8040 is a novel mutant-selective irreversible EGFRT790M inhibitor, does not inhibit ERBB2 phosphorylation (T798I).
