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PVZB-1194

CAS No. 1141768-04-8

PVZB-1194 ( PVZB1194 )

Catalog No. M10501 CAS No. 1141768-04-8

PVZB-1194 is a bis(hetero)aryl derivative that inhibits kinesin spindle protein (KSP) ATPase witn IC50 of 0.12 uM.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

PVZB-1194
Note

Research use only, not for human use.
Brief Description

PVZB-1194 is a bis(hetero)aryl derivative that inhibits kinesin spindle protein (KSP) ATPase witn IC50 of 0.12 uM.
Description

PVZB-1194 is a bis(hetero)aryl derivative that inhibits kinesin spindle protein (KSP) ATPase witn IC50 of 0.12 uM; inhibits HeLa cell proliferation with IC50 of 5.5 uM; potently inhibits KSP in a microruble dependent manner and induces a monoastral phenotype to arrest mitotic progression, abnormal KSP localization.
Synonyms

PVZB1194
Pathway

Cytoskeleton/Cell Adhesion Molecules
Target

Kinesin
Recptor

Kinesin
Research Area

——
Indication

——

Chemical Information

CAS Number

1141768-04-8
Formula Weight

319.27
Molecular Formula

C13H9F4NO2S
Purity

>98% (HPLC)
Solubility

——
SMILES

——
Chemical Name

4-[3-fluoro-4-(trifluoromethyl)phenyl]benzenesulfonamide

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Matsuno K, et al. Bioorg Med Chem Lett. 2009 Feb 15;19(4):1058-61.
2. Yokoyama H, et al. ACS Chem Biol. 2015 Apr 17;10(4):1128-36.

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