SB-743921

Research use only, not for human use.

SB-743921 is a potent, selective kinesin spindle protein (KSP) inhibitor with Ki of 0.1 nM.

SB-743921 is a potent, selective kinesin spindle protein (KSP) inhibitor with Ki of 0.1 nM, shows no activity against MKLP1, Kin2, Kif1A, Kif15, KHC, Kif4 and CENP-E; also shows high affinity for mouse KSP with Ki of 0.12 nM; blocks assembly of a functional mitotic spindle, thereby causing cell cycle arrest in mitosis and subsequent cell death in cancer cells, demonstrates improved potency over ispinesib in both biochemical and cellular assays; shows a broad spectrum of tumor inhibition in multiple cancer models.Blood Cancer Phase 2 Discontinued

SB743921;SB 743921

Cytoskeleton/Cell Adhesion Molecules

Kinesin

KSP;KSP(Colo205cells);KSP(MV522cells);KSP(MX1cells);KSP(SKOV3cells)

Cancer

Blood cancer

940929-33-9

553.52

C31H34Cl2N2O3

>98% (HPLC)

10 mM in DMSO

CC1=CC=C(C=C1)C(=O)N(CCCN)C(C2=C(C(=O)C3=C(O2)C=C(C=C3)Cl)CC4=CC=CC=C4)C(C)C.Cl

Benzamide, N-(3-aminopropyl)-N-[(1R)-1-[7-chloro-4-oxo-3-(phenylmethyl)-4H-1-benzopyran-2-yl]-2-methylpropyl]-4-methyl-, hydrochloride (1:1)

(-20℃)

With Ice Pack

≥ 2 years