Punicalin

CAS No. 65995-64-4

Punicalin( —— )

Catalog No. M20184 CAS No. 65995-64-4

Punicalin exerts anti-inflammatory antioxidative and anti-hepatotoxic activities it shows inhibitory activity on HIV-1 reverse transcriptase in a dose-dependent manner with an IC50 of 0.11 microg/ml (0.14 microM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Punicalin
  • Note
    Research use only, not for human use.
  • Brief Description
    Punicalin exerts anti-inflammatory antioxidative and anti-hepatotoxic activities it shows inhibitory activity on HIV-1 reverse transcriptase in a dose-dependent manner with an IC50 of 0.11 microg/ml (0.14 microM).
  • Description
    Punicalin exerts anti-inflammatory antioxidative and anti-hepatotoxic activities it shows inhibitory activity on HIV-1 reverse transcriptase in a dose-dependent manner with an IC50 of 0.11 microg/ml (0.14 microM).
  • In Vitro
    Western Blot Analysis Cell Line:J774A Concentration:0, 25, 50, 100 μM Incubation Time:The cells were pretreated with punicalin for one hour, followed by treated with Lipopolysaccharide (HY-D1056) for 5.5 h, ATP for half an hour, respectively.Result:Reduced the increased protein expression of NLRP3, ASC, Caspase-1 and GSDMD-N.Cell Cycle Analysis Cell Line:SH-SY5Y Concentration:10, 20 μM Incubation Time:24-72 h Result:Alleviated the rising of the G0/G1 phase ratio.Ameliorated OGD/R-mediated expression of cyclin B1, CDK1, p21 and phosphorylation of CDK1 at 20 μM.Cell Viability Assay Cell Line:J774A Concentration:0, 25, 50, 100 μM Incubation Time:24 h Result:Promoted cell viability and decreased the release of pro-inflammatory cytokines.
  • In Vivo
    Animal Model:Carrageenan (HY-125474)-induced Edema in rats Dosage:5 mg/kg Administration:s.c.Result:Showed significant anti-inflammatory effect against carrageenan induced paw edema at all time intervals, but decreased the effects.with larger dose.Animal Model:LPS (HY-D1056)-induced acute lung injury mice Dosage:10 mg/kg Administration:i.p.Result:Reduced the mortality and attenuated the severity of lung pathological injury.Ameliorated LPS (HY-D1056)-induced lung edema and vascular leakage.
  • Synonyms
    ——
  • Pathway
    Microbiology/Virology
  • Target
    HIV
  • Recptor
    HIV-1
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    65995-64-4
  • Formula Weight
    782.52
  • Molecular Formula
    C34H22O22
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?H2O : 50 mg/mL (63.90 mM)
  • SMILES
    OC1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(O)c(O)c4oc(=O)c5c(c(O)c(O)c6oc(=O)c3c4c56)-c3c(O)c(O)c(O)cc3C(=O)O[C@H]2[C@H](O)[C@H]1O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Lin CC et al. Effects of punicalagin and punicalin on carrageenan-induced inflammation in rats.Am J Chin Med. 1999;27(3-4):371-6.
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