
Punicalin
CAS No. 65995-64-4
Punicalin( —— )
Catalog No. M20184 CAS No. 65995-64-4
Punicalin exerts anti-inflammatory antioxidative and anti-hepatotoxic activities it shows inhibitory activity on HIV-1 reverse transcriptase in a dose-dependent manner with an IC50 of 0.11 microg/ml (0.14 microM).
Purity : >98% (HPLC)






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Biological Information
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Product NamePunicalin
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NoteResearch use only, not for human use.
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Brief DescriptionPunicalin exerts anti-inflammatory antioxidative and anti-hepatotoxic activities it shows inhibitory activity on HIV-1 reverse transcriptase in a dose-dependent manner with an IC50 of 0.11 microg/ml (0.14 microM).
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DescriptionPunicalin exerts anti-inflammatory antioxidative and anti-hepatotoxic activities it shows inhibitory activity on HIV-1 reverse transcriptase in a dose-dependent manner with an IC50 of 0.11 microg/ml (0.14 microM).
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In VitroWestern Blot Analysis Cell Line:J774A Concentration:0, 25, 50, 100 μM Incubation Time:The cells were pretreated with punicalin for one hour, followed by treated with Lipopolysaccharide (HY-D1056) for 5.5 h, ATP for half an hour, respectively.Result:Reduced the increased protein expression of NLRP3, ASC, Caspase-1 and GSDMD-N.Cell Cycle Analysis Cell Line:SH-SY5Y Concentration:10, 20 μM Incubation Time:24-72 h Result:Alleviated the rising of the G0/G1 phase ratio.Ameliorated OGD/R-mediated expression of cyclin B1, CDK1, p21 and phosphorylation of CDK1 at 20 μM.Cell Viability Assay Cell Line:J774A Concentration:0, 25, 50, 100 μM Incubation Time:24 h Result:Promoted cell viability and decreased the release of pro-inflammatory cytokines.
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In VivoAnimal Model:Carrageenan (HY-125474)-induced Edema in rats Dosage:5 mg/kg Administration:s.c.Result:Showed significant anti-inflammatory effect against carrageenan induced paw edema at all time intervals, but decreased the effects.with larger dose.Animal Model:LPS (HY-D1056)-induced acute lung injury mice Dosage:10 mg/kg Administration:i.p.Result:Reduced the mortality and attenuated the severity of lung pathological injury.Ameliorated LPS (HY-D1056)-induced lung edema and vascular leakage.
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Synonyms——
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PathwayMicrobiology/Virology
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TargetHIV
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RecptorHIV-1
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Research Area——
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Indication——
Chemical Information
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CAS Number65995-64-4
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Formula Weight782.52
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Molecular FormulaC34H22O22
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Purity>98% (HPLC)
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SolubilityIn Vitro:?H2O : 50 mg/mL (63.90 mM)
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SMILESOC1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(O)c(O)c4oc(=O)c5c(c(O)c(O)c6oc(=O)c3c4c56)-c3c(O)c(O)c(O)cc3C(=O)O[C@H]2[C@H](O)[C@H]1O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Lin CC et al. Effects of punicalagin and punicalin on carrageenan-induced inflammation in rats.Am J Chin Med. 1999;27(3-4):371-6.
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