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Saquinavir

CAS No. 127779-20-8

Saquinavir ( Ro 31-8959 )

Catalog No. M11152 CAS No. 127779-20-8

Apotent and selective inhibitor of HIV-1 protease with IC50 of 0.5-6 nM in cell assays.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Saquinavir
  • Note
    Research use only, not for human use.
  • Brief Description
    Apotent and selective inhibitor of HIV-1 protease with IC50 of 0.5-6 nM in cell assays.
  • Description
    Apotent and selective inhibitor of HIV-1 protease with IC50 of 0.5-6 nM in cell assays; binds to the active site of the viral protease and prevents cleavage of viral polyproteins, preventing maturation of the virus; inhibits both HIV-1 and HIV-2 proteases; used to treat or prevent HIV/AIDS.HIV Infection Approved
  • Synonyms
    Ro 31-8959
  • Pathway
    Microbiology/Virology
  • Target
    HIV
  • Recptor
    HIV
  • Research Area
    Infection
  • Indication
    HIV Infection

Chemical Information

  • CAS Number
    127779-20-8
  • Formula Weight
    670.84
  • Molecular Formula
    C38H50N6O5
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    CC(C)(C)NC(=O)C1CC2CCCCC2CN1CC(C(CC3=CC=CC=C3)NC(=O)C(CC(=O)N)NC(=O)C4=NC5=CC=CC=C5C=C4)O
  • Chemical Name
    Butanediamide, N1-[(1S,2R)-3-[(3S,4aS,8aS)-3-[[(1,1-dimethylethyl)amino]carbonyl]octahydro-2(1H)-isoquinolinyl]-2-hydroxy-1-(phenylmethyl)propyl]-2-[(2-quinolinylcarbonyl)amino]-, (2S)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Martin JA, et al. Biochem Biophys Res Commun. 1991 Apr 15;176(1):180-8.
2. Craig JC, et al. Antiviral Res. 1991 Dec;16(4):295-305.
3. Krusslich HG. J Virol. 1992 Jan;66(1):567-72.
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