Nelfinavir

CAS No. 159989-64-7

Nelfinavir( AG-1343 )

Catalog No. M12295 CAS No. 159989-64-7

A potent and orally bioavailable HIV-1 protease inhibitor with Ki of 2 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 46 In Stock
5MG 72 In Stock
10MG 102 In Stock
25MG 159 In Stock
50MG 205 In Stock
100MG 270 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    Nelfinavir
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent and orally bioavailable HIV-1 protease inhibitor with Ki of 2 nM.
  • Description
    A potent and orally bioavailable HIV-1 protease inhibitor with Ki of 2 nM; exhibits an antiviral EC50 of 30 nM in HIV-1 strain RF-infected CEM-SS cells; also inhibits the proliferation of NSCLC cells, as well as every cell line in the NCI60 cell line panel with mean GI50 of 5.2 uM, induces endoplasmic reticulum stress, autophagy, and apoptosis in vitro and in vivo.HIV Infection Approved.
  • In Vitro
    Cell Proliferation AssayCell Line:RPMI, LP1, U266, OPM2 and MM1S cells Concentration:1, 2, 5, 10 μM Incubation Time:48 hours Result:Inhibited the proliferation of RPMI, LP1, U266, OPM2 and MM1S cell lines in a dose-dependent manner with an IC50 of 1-5 μM. Apoptosis Analysis Cell Line:LP1 and U266 cells Concentration:1-10 μM Incubation Time:17 hours Result:Induced a dose-dependent increase in the percentage of annexin V+/propidium iodide+ cells. Western Blot Analysis Cell Line:U266 cells Concentration:5 μM Incubation Time:0-24 hours Result:The level of AKT phosphorylation in U266 cells decreased.
  • In Vivo
    Animal Model:NOD/SCID mice (bearing U266-luc cells) Dosage:75 mg/kg Administration:I.p.; 5 days a week for 21 days Result:Decreased MM cell growth in NOD/SCID mice.
  • Synonyms
    AG-1343
  • Pathway
    Microbiology/Virology
  • Target
    HIV
  • Recptor
    HIV
  • Research Area
    Infection
  • Indication
    HIV Infection

Chemical Information

  • CAS Number
    159989-64-7
  • Formula Weight
    567.784
  • Molecular Formula
    C32H45N3O4S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 25 mg/mL. 44.03 mM
  • SMILES
    CC1=C(C=CC=C1O)C(=O)NC(CSC2=CC=CC=C2)C(CN3CC4CCCCC4CC3C(=O)NC(C)(C)C)O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Zhang KE, et al. Antimicrob Agents Chemother. 2001 Apr;45(4):1086-93. 2. Shetty BV, et al. Antimicrob Agents Chemother. 1996 Jan;40(1):110-4. 3. Gills JJ, et al. Clin Cancer Res. 2007 Sep 1;13(17):5183-94.
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