
Nelfinavir
CAS No. 159989-64-7
Nelfinavir( AG-1343 )
Catalog No. M12295 CAS No. 159989-64-7
A potent and orally bioavailable HIV-1 protease inhibitor with Ki of 2 nM.
Purity : >98% (HPLC)






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2MG | 46 | In Stock |
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10MG | 102 | In Stock |
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50MG | 205 | In Stock |
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100MG | 270 | In Stock |
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Biological Information
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Product NameNelfinavir
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NoteResearch use only, not for human use.
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Brief DescriptionA potent and orally bioavailable HIV-1 protease inhibitor with Ki of 2 nM.
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DescriptionA potent and orally bioavailable HIV-1 protease inhibitor with Ki of 2 nM; exhibits an antiviral EC50 of 30 nM in HIV-1 strain RF-infected CEM-SS cells; also inhibits the proliferation of NSCLC cells, as well as every cell line in the NCI60 cell line panel with mean GI50 of 5.2 uM, induces endoplasmic reticulum stress, autophagy, and apoptosis in vitro and in vivo.HIV Infection Approved.
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In VitroCell Proliferation AssayCell Line:RPMI, LP1, U266, OPM2 and MM1S cells Concentration:1, 2, 5, 10 μM Incubation Time:48 hours Result:Inhibited the proliferation of RPMI, LP1, U266, OPM2 and MM1S cell lines in a dose-dependent manner with an IC50 of 1-5 μM. Apoptosis Analysis Cell Line:LP1 and U266 cells Concentration:1-10 μM Incubation Time:17 hours Result:Induced a dose-dependent increase in the percentage of annexin V+/propidium iodide+ cells. Western Blot Analysis Cell Line:U266 cells Concentration:5 μM Incubation Time:0-24 hours Result:The level of AKT phosphorylation in U266 cells decreased.
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In VivoAnimal Model:NOD/SCID mice (bearing U266-luc cells) Dosage:75 mg/kg Administration:I.p.; 5 days a week for 21 days Result:Decreased MM cell growth in NOD/SCID mice.
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SynonymsAG-1343
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PathwayMicrobiology/Virology
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TargetHIV
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RecptorHIV
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Research AreaInfection
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IndicationHIV Infection
Chemical Information
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CAS Number159989-64-7
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Formula Weight567.784
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Molecular FormulaC32H45N3O4S
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 25 mg/mL. 44.03 mM
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SMILESCC1=C(C=CC=C1O)C(=O)NC(CSC2=CC=CC=C2)C(CN3CC4CCCCC4CC3C(=O)NC(C)(C)C)O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Zhang KE, et al. Antimicrob Agents Chemother. 2001 Apr;45(4):1086-93.
2. Shetty BV, et al. Antimicrob Agents Chemother. 1996 Jan;40(1):110-4.
3. Gills JJ, et al. Clin Cancer Res. 2007 Sep 1;13(17):5183-94.
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