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Merestinib

CAS No. 1206799-15-6

Merestinib ( LY2801653 )

Catalog No. M17192 CAS No. 1206799-15-6

LY2801653 is an orally available, small molecule inhibitor of the proto-oncogene c-Met (Ki: 2 nM) with potential antineoplastic activity.

Purity : 95%

COA Datasheet HNMR HPLC MSDS Handing Instructions
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2MG 58 In Stock
5MG 96 In Stock
10MG 132 In Stock
25MG 240 In Stock
50MG 402 In Stock
100MG 573 In Stock
500MG 1197 In Stock
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Biological Information

  • Product Name
    Merestinib
  • Note
    Research use only, not for human use.
  • Brief Description
    LY2801653 is an orally available, small molecule inhibitor of the proto-oncogene c-Met (Ki: 2 nM) with potential antineoplastic activity.
  • Description
    LY2801653 is an orally available, small molecule inhibitor of the proto-oncogene c-Met (Ki: 2 nM) with potential antineoplastic activity. LY2801653 selectively binds to c-Met, thereby inhibiting c-Met phosphorylation and disrupting c-Met signal transduction pathways. This may induce cell death in tumor cells overexpressing c-Met protein or expressing the constitutively activated c-Met protein.
  • Synonyms
    LY2801653
  • Pathway
    Cytoskeleton/Cell Adhesion Molecules
  • Target
    Kinesin
  • Recptor
    Met
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1206799-15-6
  • Formula Weight
    552.54
  • Molecular Formula
    C30H22F2N6O3
  • Purity
    95%
  • Solubility
    DMSO : ≥ 32 mg/mL. 57.92 mM
  • SMILES
    c1(=O)c(ccc(n1c1ccc(cc1)F)C)C(=O)Nc1cc(c(cc1)Oc1cc2cnn(c2cc1c1cn[nH]c1)C)F
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Yan SB, Peek VL, Ajamie R, et al. Invest New Drugs. 2012 Dec 29. [Epub ahead of print]
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