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Kif15-IN-1

CAS No. 672926-32-8

Kif15-IN-1 ( KIF15-IN-1; KIF15IN-1; KIF15-IN1; KIF15IN1; KIF15 IN 1 )

Catalog No. M15567 CAS No. 672926-32-8

Kif15-IN-1 is a potent, selective inhibitor of KIF15 motility, can act synergistically with Eg5 inhibitors to impair cancer cell proliferation.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Kif15-IN-1
  • Note
    Research use only, not for human use.
  • Brief Description
    Kif15-IN-1 is a potent, selective inhibitor of KIF15 motility, can act synergistically with Eg5 inhibitors to impair cancer cell proliferation.
  • Description
    Kif15-IN-1 is a potent, selective inhibitor of KIF15 motility, can act synergistically with Eg5 inhibitors to impair cancer cell proliferation.
  • Synonyms
    KIF15-IN-1; KIF15IN-1; KIF15-IN1; KIF15IN1; KIF15 IN 1
  • Pathway
    Cytoskeleton/Cell Adhesion Molecules
  • Target
    Kinesin
  • Recptor
    Kinesin
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    672926-32-8
  • Formula Weight
    430.48
  • Molecular Formula
    C20H22N4O5S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 100 mg/mL 232.30 mM; H2O : < 0.1 mg/mL
  • SMILES
    O=C(C1=C(C)N=C(NC([C@@H](N2C(NC3=C(C=CC=C3)C2=O)=O)C(C)C)=O)S1)OCC
  • Chemical Name
    ethyl (S)-2-(2-(2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)-3-methylbutanamido)-4-methylthiazole-5-carboxylate

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Preparation of quinazolinediones as Kif15 kinesin inhibitors for treating cellular proliferative disorders. Pat. Appl. Publ. (2004), US 20040053948 A1 20040318.
2. Milic B, et al. Proc Natl Acad Sci U S A. 2018 Apr 27. pii: 201801242.
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