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TUG-891
CAS No. 1374516-07-0
TUG-891( TUG-891 | TUG 891 | TUG891 )
Catalog No. M17264 CAS No. 1374516-07-0
TUG-891 is a G protein-coupled receptor (GPCR) expressed in intestine, adipocytes, and pro-inflammatory macrophages that is activated by long chain free fatty acids.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 42 | In Stock |
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| 5MG | 69 | In Stock |
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| 10MG | 105 | In Stock |
|
| 25MG | 213 | In Stock |
|
| 50MG | 357 | In Stock |
|
| 100MG | 524 | In Stock |
|
| 500MG | 1107 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameTUG-891
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NoteResearch use only, not for human use.
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Brief DescriptionTUG-891 is a G protein-coupled receptor (GPCR) expressed in intestine, adipocytes, and pro-inflammatory macrophages that is activated by long chain free fatty acids.
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DescriptionTUG-891 is a potent and selective agonist of the free fatty acid receptor 4 (FFA4/GPR120), which demonstrates both potential opportunity and possible challenges to therapeutic agonism. Activation of human FFA4 by TUG-891 also resulted in rapid phosphorylation and internalization of the receptor. TUG-891 was also a potent agonist of mouse FFA4, but it showed only limited selectivity over mouse FFA1, complicating its use in vivo in this species.
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In VitroTUG-891 displays similar signaling properties to the LCFA α-linolenic acid at human FFA4, including stimulation of Ca2+ mobilization, β-arrestin-1 and β-arrestin-2 recruitment, and extracellular signal-regulated kinase phosphorylation. Activation of human FFA4 by TUG-891 also results in rapid phosphorylation and internalization of the receptor.
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In Vivo——
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SynonymsTUG-891 | TUG 891 | TUG891
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PathwayCytoskeleton/Cell Adhesion Molecules
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TargetKinesin
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RecptorGPR120
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Research AreaMetabolic Disease
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Indication——
Chemical Information
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CAS Number1374516-07-0
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Formula Weight364.41
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Molecular FormulaC23H21FO3
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 180 mg/mL 493.95 mM
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SMILESc1(c(ccc(c1)F)c1ccc(cc1)C)COc1ccc(cc1)CCC(=O)O
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Chemical Name3-(4-((4-fluoro-4'-methyl-[1,1'-biphenyl]-2-yl)methoxy)phenyl)propanoic acid
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Hopkins MM, Zhang Z, Liu Z, Meier KE. J Clin Med. 2016 Jan 26;5(2).
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