TUG-891( TUG-891 | TUG 891 | TUG891 )

Catalog No. M17264 CAS No. 1374516-07-0

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

TUG-891
Note

Research use only, not for human use.
Brief Description

TUG-891 is a G protein-coupled receptor (GPCR) expressed in intestine, adipocytes, and pro-inflammatory macrophages that is activated by long chain free fatty acids.
Description

TUG-891 is a potent and selective agonist of the free fatty acid receptor 4 (FFA4/GPR120), which demonstrates both potential opportunity and possible challenges to therapeutic agonism. Activation of human FFA4 by TUG-891 also resulted in rapid phosphorylation and internalization of the receptor. TUG-891 was also a potent agonist of mouse FFA4, but it showed only limited selectivity over mouse FFA1, complicating its use in vivo in this species.
In Vitro

TUG-891 displays similar signaling properties to the LCFA α-linolenic acid at human FFA4, including stimulation of Ca2+ mobilization, β-arrestin-1 and β-arrestin-2 recruitment, and extracellular signal-regulated kinase phosphorylation. Activation of human FFA4 by TUG-891 also results in rapid phosphorylation and internalization of the receptor.
In Vivo

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Synonyms

TUG-891 | TUG 891 | TUG891
Pathway

Cytoskeleton/Cell Adhesion Molecules
Target

Kinesin
Recptor

GPR120
Research Area

Metabolic Disease
Indication

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CAS Number

1374516-07-0
Formula Weight

364.41
Molecular Formula

C23H21FO3
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 180 mg/mL 493.95 mM
SMILES

c1(c(ccc(c1)F)c1ccc(cc1)C)COc1ccc(cc1)CCC(=O)O
Chemical Name

3-(4-((4-fluoro-4'-methyl-[1,1'-biphenyl]-2-yl)methoxy)phenyl)propanoic acid

1.Hopkins MM, Zhang Z, Liu Z, Meier KE. J Clin Med. 2016 Jan 26;5(2).

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