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Ro24-7429
CAS No. 139339-45-0
Ro24-7429( Ro 24-7429 | Ro-24-7429 | Ro 247429 )
Catalog No. M27924 CAS No. 139339-45-0
Ro24-7429 is an effective and orally active antagonist of HIV-1 transactivator protein Tat and an inhibitor of a runt-related transcription factor 1.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 215 | In Stock |
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| 5MG | 187 | In Stock |
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| 10MG | 297 | In Stock |
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| 25MG | 506 | In Stock |
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| 50MG | 714 | In Stock |
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| 100MG | 1004 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | 2816 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameRo24-7429
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NoteResearch use only, not for human use.
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Brief DescriptionRo24-7429 is an effective and orally active antagonist of HIV-1 transactivator protein Tat and an inhibitor of a runt-related transcription factor 1.
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DescriptionRo24-7429 is an effective and orally active antagonist of HIV-1 transactivator protein Tat and an inhibitor of a runt-related transcription factor 1. Ro24-7429 has anti-HIV, antifibrotic, and anti-inflammatory effects.(In Vitro):Ro24-7429 (50-200 μM; 24-72 hours) strongly inhibits the proliferation of A549 and HLF cells in a dose-dependent manner. Ro24-7429 treatment (75 μM) significantly reduces TNF-α-induced up-regulation of RUNX1 mRNA by 50% at 48 hours. Ro 24-7429 (1-25 μM) induces apoptosis and inhibits antigen-induced lymphocyte proliferation. Ro 24-7429 (0.1 μM, 1 μM, 5 μM; 3 days) induces apoptosis of cultured PBMCs in a dose-dependent manner.(In Vivo):Ro24-7429 (17.5-70 mg/kg; i.p.) curbs expression of fibrosis markers in injured mouse lungs. Ro24-7429 robustly ameliorates lung fibrosis and inflammation in the Bleomycin-induced pulmonary fibrosis mouse model.
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In VitroApoptosis Analysis Cell Line:Peripheral blood mononuclear cells (PBMCs) Concentration:0.1 μM, 1 μM, 5 μM Incubation Time:3 days Result:Induced a dose-dependent increase in apoptosis of cultured PBMCs.
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In VivoAnimal Model:C57BL/6J male and female mice (aged 6 to 8 weeks) induced by Bleomycin Dosage:17.5 mg/kg, 35 mg/kg, and 70 mg/kg Administration:i.p.; daily; for 14 or 21 days Result:Ameliorated lung fibrosis and inflammation in the Bleomycin-induced PF mouse model.
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SynonymsRo 24-7429 | Ro-24-7429 | Ro 247429
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PathwayMicrobiology/Virology
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TargetHIV
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number139339-45-0
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Formula Weight272.74
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Molecular FormulaC14H13ClN4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 62.5 mg/mL (229.16 mM)
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SMILESCNC1=Nc2ccc(Cl)cc2C(=NC1)c1ccc[nH]1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Planchestainer M, et al. Widely applicable background depletion step enables transaminase evolution through solid-phase screening. Chem Sci. 2019 May 9;10(23):5952-5958.
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