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NBD-557

CAS No. 333352-59-3

NBD-557( NBD 557 | NBD557 )

Catalog No. M14122 CAS No. 333352-59-3

A potent HIV-1 entry inhibitor that blocks the gp120-CD4 interaction; inhibits the fusion between HIV-1NL4-3-luc pseudotyped virus expressing HIV-1HXB2 (X4-tropic) envelope and U87-T4-CXCR4 cells with IC50 of 9.7 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 71 In Stock
5MG 65 In Stock
10MG 105 In Stock
25MG 211 In Stock
50MG 300 In Stock
100MG 425 In Stock
200MG 578 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    NBD-557
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent HIV-1 entry inhibitor that blocks the gp120-CD4 interaction; inhibits the fusion between HIV-1NL4-3-luc pseudotyped virus expressing HIV-1HXB2 (X4-tropic) envelope and U87-T4-CXCR4 cells with IC50 of 9.7 uM.
  • Description
    A potent HIV-1 entry inhibitor that blocks the gp120-CD4 interaction; inhibits the fusion between HIV-1NL4-3-luc pseudotyped virus expressing HIV-1HXB2 (X4-tropic) envelope and U87-T4-CXCR4 cells with IC50 of 9.7 uM; inhibits the laboratory-adapted HIV-1 strains IIIB, MN, and V32 with IC50 of 5-16 uM.HIV Infection Preclinical.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    NBD 557 | NBD557
  • Pathway
    Microbiology/Virology
  • Target
    HIV
  • Recptor
    HIV
  • Research Area
    Infection
  • Indication
    HIV Infection

Chemical Information

  • CAS Number
    333352-59-3
  • Formula Weight
    382.2953
  • Molecular Formula
    C17H24BrN3O2
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    O=C(NC1=CC=C(Br)C=C1)C(NC2CC(C)(C)NC(C)(C)C2)=O
  • Chemical Name
    Ethanediamide, N-(4-bromophenyl)-N'-(2,2,6,6-tetramethyl-4-piperidinyl)- (9CI)

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Zhao Q, et al. Virology. 2005 Sep 1;339(2):213-25. 2. Sch?n A, et al. Biochemistry. 2006 Sep 12;45(36):10973-80. 3. Curreli F, et al. Antimicrob Agents Chemother. 2014 Sep;58(9):5478-91.
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