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Anagrelide HCl
CAS No. 58579-51-4
Anagrelide HCl( Anagrelide hydrochloride | BL 4162A | GALE-401 | Thromboreductin )
Catalog No. M18853 CAS No. 58579-51-4
Anagrelide Hydrochloride(BL4162A) is a drug used for the treatment of essential thrombocytosis.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 29 | In Stock |
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| 10MG | 44 | In Stock |
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| 25MG | 77 | In Stock |
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| 50MG | 142 | In Stock |
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| 100MG | 230 | In Stock |
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| 200MG | 341 | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameAnagrelide HCl
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NoteResearch use only, not for human use.
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Brief DescriptionAnagrelide Hydrochloride(BL4162A) is a drug used for the treatment of essential thrombocytosis.
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DescriptionAnagrelide hydrochloride, also known as Agrylin, is a drug used for the treatment of essential thrombocytosis---overproduction of blood platelets. It also has been used in the treatment of chronic myeloid leukemia. Anagrelide controlled release (GALE-401) is in phase III clinical trials by Galena Biopharma for the treatment of essential thrombocytosis.
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In VitroCell Viability Assay Cell Line:Megakaryocytic and non-megakaryocytic cells Concentration:0.05, 0.3, 1 μM Incubation Time:12-dayResult:Inhibited only megakaryocytic cell growth at every concentration tested.Cell Cytotoxicity Assay Cell Line:GIST882 and GIST48 cell line Concentration:0.1, 1, 10, 100, 1000, 10000 nM Incubation Time:Result:Induced a cytotoxic effect in the GIST882 cell line (IC50= 16 nM), but was only weakly active in the GIST48 cell line.
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In VivoAnimal Model:Adult female athymic mice bearing GIST2B, GIST3, GIST9, GIST882 model Dosage:5 mg/kg Administration:Twice daily; for 10 days Result:Inhibited or reduced tumor growth in three (GIST2B, GIST9, GIST882) of these four models.
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SynonymsAnagrelide hydrochloride | BL 4162A | GALE-401 | Thromboreductin
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PathwayMicrobiology/Virology
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TargetHIV
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RecptorPDE
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Research AreaInflammation/Immunology
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Indication——
Chemical Information
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CAS Number58579-51-4
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Formula Weight292.55
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Molecular FormulaC10H7Cl2N3O·HCl
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Purity>98% (HPLC)
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SolubilityDMSO : 7.69 mg/mL 26.29 mM; H2O : < 0.1 mg/mL
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SMILESCl.ClC1=CC=C2NC3=NC(=O)CN3CC2=C1Cl
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Chemical NameImidazo(2,1-b)quinazolin-2(3H)-one, 6,7-dichloro-1,5-dihydro-, monohydrochloride
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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I-XW-053
I-XW-053 is an inhibitor of capsid targeted HIV-1 replication using the hybrid structure based method to block the interface between CA N-terminal domains (NTD-NTD interface) with micromolar affinity.
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HIV-1 inhibitor-54
HIV-1 inhibitor-54 is a potent inhibitor of WT HIV-1 (strain IIIB) in MT-4 cells, demonstrating anti-HIV activity with an EC50 of 32 nM. [HIV-1 inhibitor-54 can be used to study viral infections.]
