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TTP-8307
CAS No. 950225-08-8
TTP-8307( TTP8307 )
Catalog No. M16795 CAS No. 950225-08-8
TTP-8307 is a potent inhibitor of the replication of several Rhinoviruses and Enteroviruses.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 239 | Get Quote |
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| 50MG | 1116 | Get Quote |
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| 100MG | 1791 | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameTTP-8307
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NoteResearch use only, not for human use.
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Brief DescriptionTTP-8307 is a potent inhibitor of the replication of several Rhinoviruses and Enteroviruses.
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DescriptionTTP-8307 is a potent inhibitor of the replication of several Rhinoviruses and Enteroviruses, targets the nonstructural protein 3A, inhibits the replication of coxsackievirus B3 (CVB3 Nancy) with EC50 of 1.2 uM; 3A mutations V45A, I54F, and H57Y confer resistance to TTP-8307.
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In VitroTTP-8307 targets the nonstructural protein 3A, inhibits the replication of coxsackievirus B3 (CVB3 Nancy) with EC50 of 1.2 μM. TTP-8307 inhibits the replication of coxsackievirus B3 and the three poliovirus Sabin strains, as well as coxsackieviruses A16 and A21 (EC50 of 0.85 and 5.34 μM). TTP-8307 inhibits human rhinoviruses (HRVs) 2, 29, 39, 45, 63, and 85. Mutations in the nonstructural protein 3A confer resistance to the novel enterovirus replication inhibitor TTP-8307.TTP-8307 inhibits OSBP-dependent viruses encephalomyocarditis virus (EMCV) and HCV.
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In Vivo——
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SynonymsTTP8307
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PathwayMicrobiology/Virology
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TargetEnterovirus
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RecptorEnterovirus
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Research Area——
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Indication——
Chemical Information
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CAS Number950225-08-8
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Formula Weight436.49
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Molecular FormulaC27H21FN4O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (229.11 mM)
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SMILES——
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Chemical NameN-[(1R)-1-(4-Fluorophenyl)ethyl]-3-[2-(isoquinolin-3-yl)-1H-imidazol-4-yl]benzamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. De Palma AM, et al. Antimicrob Agents Chemother. 2009 May;53(5):1850-7.
2. Arita M, et al. J Virol. 2011 Mar;85(5):2364-72.
3. Norder H, et al. Antiviral Res. 2011 Mar;89(3):204-18.
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