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OSW-1

CAS No. 145075-81-6

OSW-1( OSW1 )

Catalog No. M11937 CAS No. 145075-81-6

OSW-1 is a natural anti-enterovirus and anti-cancer compound that targets oxysterol-binding protein (OSBP) with Ki of 26 and 54 nM for OSBP and ORP4L, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    OSW-1
  • Note
    Research use only, not for human use.
  • Brief Description
    OSW-1 is a natural anti-enterovirus and anti-cancer compound that targets oxysterol-binding protein (OSBP) with Ki of 26 and 54 nM for OSBP and ORP4L, respectively.
  • Description
    OSW-1 is a natural anti-enterovirus and anti-cancer compound that targets oxysterol-binding protein (OSBP) with Ki of 26 and 54 nM for OSBP and ORP4L, respectively; potently inhibits the replication of enteroviruses with IC50 values in the low nanomolar range; exhibits antiproliferative activity in HCT-116 and HeLa cell lines.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    OSW1
  • Pathway
    Microbiology/Virology
  • Target
    Enterovirus
  • Recptor
    Enterovirus
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    145075-81-6
  • Formula Weight
    873.046
  • Molecular Formula
    C47H68O15
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (114.54 mM)
  • SMILES
    O=C(O[C@H]1[C@H](O[C@@H]2[C@@H](OC(C)=O)[C@H](O[C@H]3C[C@@]4([H])[C@]5([H])CC=C6C[C@@H](O)CC[C@]6(C)[C@@]5([H])CC[C@]4(C)[C@@]3(O)[C@@H](C(CCC(C)C)=O)C)OC[C@@H]2O)OC[C@@H](O)[C@@H]1O)C7=CC=C(OC)C=C7
  • Chemical Name
    (3β,16β)-16-[[2-O-Acetyl-3-O-[2-O-(4-methoxybenzoyl)-β-D-xylopyranosyl]-α-L-arabinopyranosyl]oxy]-3,17-dihydroxycholest-5-en-22-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Burgett AW, et al. Nat Chem Biol. 2011 Aug 7;7(9):639-47. 2. Strating JR, et al. Cell Rep. 2015 Feb 3;10(4):600-15. 3. Zhou Y, et al. J Natl Cancer Inst. 2005 Dec 7; 97(23):1781-5. 4. Albulescu L, et al. Antiviral Res. 2015 May;117:110-4.
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