Cart
sales@molnova.com
Monastrol (b)
CAS No. 329689-23-8
Monastrol (b)( ±)-Monastrol )
Catalog No. M14088 CAS No. 329689-23-8
A potent, specific, allosteric and reversible mitotic kinesin Eg5 inhibitor with IC50 of 14 uM (microtubule motility inhibition).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 85 | In Stock |
|
| 5MG | 67 | In Stock |
|
| 10MG | 93 | In Stock |
|
| 25MG | 188 | In Stock |
|
| 50MG | 305 | In Stock |
|
| 100MG | 492 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 1051 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameMonastrol (b)
-
NoteResearch use only, not for human use.
-
Brief DescriptionA potent, specific, allosteric and reversible mitotic kinesin Eg5 inhibitor with IC50 of 14 uM (microtubule motility inhibition).
-
DescriptionA potent, specific, allosteric and reversible mitotic kinesin Eg5 inhibitor with IC50 of 14 uM (microtubule motility inhibition); does not inhibit microtubule motility driven by conventional kinesin at 200 uM; inhibits both the basal and the microtubule-stimulated ATPase activity of the Eg5 motor domain, does not compete with ATP binding to Eg5; arrests cells in mitosis with monoastral spindles, and (S)-monastrol is a more potent inhibitor of Eg5 activity in vitro and in vivo.
-
In Vitro——
-
In Vivo——
-
Synonyms±)-Monastrol
-
PathwayCytoskeleton/Cell Adhesion Molecules
-
TargetKinesin
-
RecptorEg5
-
Research AreaCancer
-
Indication——
Chemical Information
-
CAS Number329689-23-8
-
Formula Weight292.35344
-
Molecular FormulaC14H16N2O3S
-
Purity>98% (HPLC)
-
SolubilityDMSO: ≥ 33 mg/mL
-
SMILESCCOC(=O)C1=C(NC(=S)NC1C2=CC(=CC=C2)O)C
-
Chemical Name5-Pyrimidinecarboxylic acid, 1,2,3,4-tetrahydro-4-(3-hydroxyphenyl)-6-methyl-2-thioxo-, ethyl ester
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Mayer TU, et al. Science. 1999 Oct 29;286(5441):971-4.
2. Kapoor TM, et al. J Cell Biol. 2000 Sep 4;150(5):975-88.
3. DeBonis S, et al. Biochemistry. 2003 Jan 21;42(2):338-49.
4. Maliga Z, et al. Chem Biol. 2002 Sep;9(9):989-96.
molnova catalog
related products
-
MAC1
MAC1 (Monastrol Antagonizing Compound 1) is a small molecule that can rescue spindle bipolarity in cells lacking Eg5 activity.
-
K-858
A potent, selective inhibitor of mitotic kinesin Eg5 ATPase activity with IC50 of 1.3 uM.
-
MK-0731
MK-0731 is a potent, selective kinesin spindle protein (KSP) inhibitor with IC50 of 2.2 nM, cell EC50 of 5.3 nM.
