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Monastrol (b)
CAS No. 329689-23-8
Monastrol (b)( ±)-Monastrol )
Catalog No. M14088 CAS No. 329689-23-8
A potent, specific, allosteric and reversible mitotic kinesin Eg5 inhibitor with IC50 of 14 uM (microtubule motility inhibition).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 85 | In Stock |
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| 5MG | 67 | In Stock |
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| 10MG | 93 | In Stock |
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| 25MG | 188 | In Stock |
|
| 50MG | 305 | In Stock |
|
| 100MG | 492 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 1051 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameMonastrol (b)
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, specific, allosteric and reversible mitotic kinesin Eg5 inhibitor with IC50 of 14 uM (microtubule motility inhibition).
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DescriptionA potent, specific, allosteric and reversible mitotic kinesin Eg5 inhibitor with IC50 of 14 uM (microtubule motility inhibition); does not inhibit microtubule motility driven by conventional kinesin at 200 uM; inhibits both the basal and the microtubule-stimulated ATPase activity of the Eg5 motor domain, does not compete with ATP binding to Eg5; arrests cells in mitosis with monoastral spindles, and (S)-monastrol is a more potent inhibitor of Eg5 activity in vitro and in vivo.
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In Vitro——
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In Vivo——
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Synonyms±)-Monastrol
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PathwayCytoskeleton/Cell Adhesion Molecules
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TargetKinesin
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RecptorEg5
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number329689-23-8
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Formula Weight292.35344
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Molecular FormulaC14H16N2O3S
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 33 mg/mL
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SMILESCCOC(=O)C1=C(NC(=S)NC1C2=CC(=CC=C2)O)C
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Chemical Name5-Pyrimidinecarboxylic acid, 1,2,3,4-tetrahydro-4-(3-hydroxyphenyl)-6-methyl-2-thioxo-, ethyl ester
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Mayer TU, et al. Science. 1999 Oct 29;286(5441):971-4.
2. Kapoor TM, et al. J Cell Biol. 2000 Sep 4;150(5):975-88.
3. DeBonis S, et al. Biochemistry. 2003 Jan 21;42(2):338-49.
4. Maliga Z, et al. Chem Biol. 2002 Sep;9(9):989-96.
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