TUG-891

Research use only, not for human use.

TUG-891 is a G protein-coupled receptor (GPCR) expressed in intestine, adipocytes, and pro-inflammatory macrophages that is activated by long chain free fatty acids.

TUG-891 is a potent and selective agonist of the free fatty acid receptor 4 (FFA4/GPR120), which demonstrates both potential opportunity and possible challenges to therapeutic agonism. Activation of human FFA4 by TUG-891 also resulted in rapid phosphorylation and internalization of the receptor. TUG-891 was also a potent agonist of mouse FFA4, but it showed only limited selectivity over mouse FFA1, complicating its use in vivo in this species.

TUG-891 displays similar signaling properties to the LCFA α-linolenic acid at human FFA4, including stimulation of Ca2+ mobilization, β-arrestin-1 and β-arrestin-2 recruitment, and extracellular signal-regulated kinase phosphorylation. Activation of human FFA4 by TUG-891 also results in rapid phosphorylation and internalization of the receptor.

——

TUG-891 | TUG 891 | TUG891

Cytoskeleton/Cell Adhesion Molecules

Kinesin

GPR120

Metabolic Disease

——

1374516-07-0

364.41

C23H21FO3

>98% (HPLC)

DMSO : ≥ 180 mg/mL 493.95 mM

c1(c(ccc(c1)F)c1ccc(cc1)C)COc1ccc(cc1)CCC(=O)O

3-(4-((4-fluoro-4'-methyl-[1,1'-biphenyl]-2-yl)methoxy)phenyl)propanoic acid

(-20℃)

With Ice Pack

≥ 2 years