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MK-0731

CAS No. 845256-65-7

MK-0731( MK0731 )

Catalog No. M16139 CAS No. 845256-65-7

MK-0731 is a potent, selective kinesin spindle protein (KSP) inhibitor with IC50 of 2.2 nM, cell EC50 of 5.3 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    MK-0731
  • Note
    Research use only, not for human use.
  • Brief Description
    MK-0731 is a potent, selective kinesin spindle protein (KSP) inhibitor with IC50 of 2.2 nM, cell EC50 of 5.3 nM.
  • Description
    MK-0731 is a potent, selective kinesin spindle protein (KSP) inhibitor with IC50 of 2.2 nM, cell EC50 of 5.3 nM; dispalys >20,000-fold selectivity for KSP over a panel of eight related kinesins (CENP-E, MKLP-1, Kif3A, Kif1B, uKHC, nKHC, KIF14, and MCAK); induces a mitotic block with an IC50 of 19 nM in cells that are refractory to paclitaxel due to P-gp overexpression; induces dose-dependent mitotic arrest in tumors and inhibits tumor growth in mouse xenograft.Solid Tumors Discontinued.
  • In Vitro
    Apoptosis Analysis Cell Line:A2780 cells Concentration:0.415-300 nM Incubation Time:48 h Result:Induced apoptosis with an EC50 of 2.7 nM.
  • In Vivo
    ——
  • Synonyms
    MK0731
  • Pathway
    Cytoskeleton/Cell Adhesion Molecules
  • Target
    Kinesin
  • Recptor
    Kinesin
  • Research Area
    Cancer
  • Indication
    Solid Tumors

Chemical Information

  • CAS Number
    845256-65-7
  • Formula Weight
    459.513
  • Molecular Formula
    C25H28F3N3O2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(N1[C@@](C2=CC=CC=C2)(CO)C=C(C3=CC(F)=CC=C3F)C1)N([C@@H]4[C@H](F)CN(C)CC4)C
  • Chemical Name
    (S)-4-(2,5-difluorophenyl)-N-((3R,4S)-3-fluoro-1-methylpiperidin-4-yl)-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Cox CD, et al. J Med Chem. 2008 Jul 24;51(14):4239-52. 2. Cox CD, et al. Anticancer Agents Med Chem. 2010 Nov 1;10(9):697-712. 3. Holen K, et al. Invest New Drugs. 2012 Jun;30(3):1088-95.
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