MK-8267( SCH 2047069 )

Catalog No. M10516 CAS No. 1146209-50-8

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

MK-8267
Note

Research use only, not for human use.
Brief Description

MK-8267 (SCH 2047069) is a potent, orally bioavailable, brain penetrant kinesin spindle protein (KSP) inhibitor with EC50 of 3 nM.
Description

MK-8267 (SCH 2047069) is a potent, orally bioavailable, brain penetrant kinesin spindle protein (KSP) inhibitor with EC50 of 3 nM; inhibits a broader panel of 57 different tumor cell lines with IC50 <30 nM; showes significant brain uptake in mouse and rat with brain/plasma AUC ratio of 4 in rats, demonstrates anti-tumor activities in the tumor xenograft mouse model.
In Vitro

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In Vivo

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Synonyms

SCH 2047069
Pathway

Cytoskeleton/Cell Adhesion Molecules
Target

Kinesin
Recptor

Kinesin
Research Area

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Indication

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CAS Number

1146209-50-8
Formula Weight

439.429
Molecular Formula

C20H17F4N3O2S
Purity

>98% (HPLC)
Solubility

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SMILES

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Chemical Name

1-(3-(2-Aminoethyl)-5'-(2,5-difluorophenyl)-6,7-difluoro-3'H-spiro[chromane-4,2'-[1,3,4]thiadiazol]-3'-yl)ethan-1-one

1. Mansoor UF, et al. Bioorg Med Chem. 2015 May 15;23(10):2424-34.

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