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MK-8267
CAS No. 1146209-50-8
MK-8267( SCH 2047069 )
Catalog No. M10516 CAS No. 1146209-50-8
MK-8267 (SCH 2047069) is a potent, orally bioavailable, brain penetrant kinesin spindle protein (KSP) inhibitor with EC50 of 3 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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| 100MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameMK-8267
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NoteResearch use only, not for human use.
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Brief DescriptionMK-8267 (SCH 2047069) is a potent, orally bioavailable, brain penetrant kinesin spindle protein (KSP) inhibitor with EC50 of 3 nM.
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DescriptionMK-8267 (SCH 2047069) is a potent, orally bioavailable, brain penetrant kinesin spindle protein (KSP) inhibitor with EC50 of 3 nM; inhibits a broader panel of 57 different tumor cell lines with IC50 <30 nM; showes significant brain uptake in mouse and rat with brain/plasma AUC ratio of 4 in rats, demonstrates anti-tumor activities in the tumor xenograft mouse model.
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In Vitro——
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In Vivo——
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SynonymsSCH 2047069
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PathwayCytoskeleton/Cell Adhesion Molecules
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TargetKinesin
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RecptorKinesin
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Research Area——
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Indication——
Chemical Information
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CAS Number1146209-50-8
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Formula Weight439.429
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Molecular FormulaC20H17F4N3O2S
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name1-(3-(2-Aminoethyl)-5'-(2,5-difluorophenyl)-6,7-difluoro-3'H-spiro[chromane-4,2'-[1,3,4]thiadiazol]-3'-yl)ethan-1-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Mansoor UF, et al. Bioorg Med Chem. 2015 May 15;23(10):2424-34.
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