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Tolnaftate

CAS No. 2398-96-1

Tolnaftate( NSC 233648 | SCH 10144 )

Catalog No. M13694 CAS No. 2398-96-1

Tolnaftate is a synthetic thiocarbamate used as an anti-fungal agent.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Tolnaftate
  • Note
    Research use only, not for human use.
  • Brief Description
    Tolnaftate is a synthetic thiocarbamate used as an anti-fungal agent.
  • Description
    Tolnaftate is a synthetic thiocarbamate used as an anti-fungal agent.(In Vitro):Tolnaftate (NP-27) blocked sterol biosynthesis in fungal cells and cell extracts, with accumulation of squalene. This point of action was confirmed by the direct inhibition of microsomal squalene epoxidase from Candida albicans. Tolnaftate (NP-27) inhibited sterol biosynthesis, At 100 microM, tolnaftate caused up to a 30% release of intracellular [14C]aminoisobutyric acid.
  • In Vitro
    Tolnaftate (NP-27) blocked sterol biosynthesis in fungal cells and cell extracts, with accumulation of squalene. This point of action was confirmed by the direct inhibition of microsomal squalene epoxidase from Candida albicans. Tolnaftate (NP-27) inhibited sterol biosynthesis, At 100 microM, tolnaftate caused up to a 30% release of intracellular [14C]aminoisobutyric acid.
  • In Vivo
    ——
  • Synonyms
    NSC 233648 | SCH 10144
  • Pathway
    GPCR/G Protein
  • Target
    Hedgehog (Hh)
  • Recptor
    Smoothened
  • Research Area
    Infection
  • Indication
    ——

Chemical Information

  • CAS Number
    2398-96-1
  • Formula Weight
    307.42
  • Molecular Formula
    C19H17NOS
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 62 mg/mL (201.68 mM)
  • SMILES
    S=C(OC1=CC=C2C=CC=CC2=C1)N(C)C3=CC=CC(C)=C3
  • Chemical Name
    O-naphthalen-2-yl N-methyl-N-(3-methylphenyl)carbamothioate

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Barrett-Bee K, Dixon G. Acta Biochim Pol. 1995;42(4):465-79.
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