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ALLO-2

CAS No. 1357350-60-7

ALLO-2( —— )

Catalog No. M22837 CAS No. 1357350-60-7

ALLO-2 is a Inhibitor of Drug-Resistant Smo Mutant.It inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    ALLO-2
  • Note
    Research use only, not for human use.
  • Brief Description
    ALLO-2 is a Inhibitor of Drug-Resistant Smo Mutant.It inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM.
  • Description
    ALLO-2 is a Inhibitor of Drug-Resistant Smo Mutant.It inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    GPCR/G Protein
  • Target
    Hedgehog (Hh)
  • Recptor
    Smoothened
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1357350-60-7
  • Formula Weight
    371.32
  • Molecular Formula
    C18H12F3N5O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:125 mg/mL (336.64 mM; Need ultrasonic)
  • SMILES
    FC(F)(OC1=CC=C(C=C1)C2=NC(NC3=CC4=C(C=C3)NN=C4)=NC=C2)F
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Tao H, et al. Small molecule antagonists in distinct binding modes inhibit drug-resistant mutant of smoothened. Chem Biol. 2011 Apr 22;18(4):432-7.
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