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Cyclopamine tartrate

CAS No. 1178510-81-0

Cyclopamine tartrate( —— )

Catalog No. M10605 CAS No. 1178510-81-0

Cyclopamine tartrate is a natural steroidal alkaloid that inhibits hedgehog (Hh) signaling with IC50 of 46 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Cyclopamine tartrate
  • Note
    Research use only, not for human use.
  • Brief Description
    Cyclopamine tartrate is a natural steroidal alkaloid that inhibits hedgehog (Hh) signaling with IC50 of 46 nM.
  • Description
    Cyclopamine tartrate is a natural steroidal alkaloid that inhibits hedgehog (Hh) signaling with IC50 of 46 nM; inhibits hedgehog-dependent expression of Pax7 with IC50 of 24 nM, blocks the response of neural plate explants to recombinant Shh-N; A useful tool in studying the role of Hh in normal development, and as a potential treatment for certain cancers in which Hh is overexpressed.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    GPCR/G Protein
  • Target
    Hedgehog (Hh)
  • Recptor
    Hedgehog (Hh)
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1178510-81-0
  • Formula Weight
    973.32
  • Molecular Formula
    C58H88N2O10
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    (3S,3'R,3a'S,6aS,6bS,6'S,7a'R,9R,11aS,11bR)-3',6',10,11b-tetramethyl-1,2,3,3a',4,4',5',6,6a,6b,6',7,7',7a',8,11,11a,11b-octadecahydro-3'H-spiro[benzo[a]fluorene-9,2'-furo[3,2-b]pyridin]-3-ol (2R,3R)-2,3-dihydroxysuccinate

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Peukert S, et al. Bioorg Med Chem Lett. 2009 Jan 15;19(2):328-31. 2. Cooper MK, et al. Science. 1998 Jun 5;280(5369):1603-7. 3. Incardona JP, et al. Development. 1998 Sep;125(18):3553-62.
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