ICA135( ICA-135 | ICA 135 )

Catalog No. M16064 CAS No. 825601-94-3

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Datasheet

HNMR

HPLC

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Product Name

ICA135
Note

Research use only, not for human use.
Brief Description

ICA135 (ICA-135, ICA 135) is a broad-spectrum inhibitor against human enteroviruses that inhibits Coxsackievirus A10 (CV-A10) replication in RD cells with IC50 of 1.446 uM.
Description

ICA135 (ICA-135, ICA 135) is a broad-spectrum inhibitor against human enteroviruses that inhibits Coxsackievirus A10 (CV-A10) replication in RD cells with IC50 of 1.446 uM; exerts protective function in vivo in an established mouse model of CV-A10; exhibited inhibitory effect on Enteroviruses four species A-D with IC50 of 0.566 and 9.68 uM, including EV-A71 and CV-A16 from specie A, CV-B3 from specie B, PV-1 from specie C, and EV-D68 from specie D; bind to the VP1 hydrophobic pockets with high-binding affinity.
In Vitro

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In Vivo

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Synonyms

ICA-135 | ICA 135
Pathway

Microbiology/Virology
Target

Enterovirus
Recptor

Enterovirus
Research Area

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Indication

——

CAS Number

825601-94-3
Formula Weight

482.58
Molecular Formula

C30H30N2O4
Purity

>98% (HPLC)
Solubility

——
SMILES

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Chemical Name

1-(3,4-dimethoxyphenyl)-3-(1-(2-hydroxy-3-(indolin-1-yl)propyl)-1H-indol-3-yl)prop-2-en-1-one

1. Chen J, et al. Cell Discov. 2019 Jan 15;5:4. doi: 10.1038/s41421-018-0073-7.

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