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GSK-1
CAS No. 912953-25-4
GSK-1 ( —— )
Catalog No. M16555 CAS No. 912953-25-4
GSK-1 is an ATP-competitive inhibitor of the mitotic kinesin KSP with HCT116 cell IC50 of 36 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameGSK-1
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NoteResearch use only, not for human use.
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Brief DescriptionGSK-1 is an ATP-competitive inhibitor of the mitotic kinesin KSP with HCT116 cell IC50 of 36 nM.
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DescriptionGSK-1 is an ATP-competitive inhibitor of the mitotic kinesin KSP with HCT116 cell IC50 of 36 nM; induces monopolar spindle formation in SKOV3 cells, and shows markedly greater potency (IC50 of 0.5 nM) in the ispinesib-resistant HCT116-D130V cell line.
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Synonyms——
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PathwayCytoskeleton/Cell Adhesion Molecules
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TargetKinesin
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RecptorKinesin
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Research Area——
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Indication——
Chemical Information
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CAS Number912953-25-4
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Formula Weight291.27
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Molecular FormulaC16H12F3NO
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Purity>98% (HPLC)
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Solubility——
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SMILESC1CC(=O)NC2=C1C=C(C=C2)C3=CC=C(C=C3)C(F)(F)F
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Chemical Name6-(4-(trifluoromethyl)phenyl)-3,4-dihydroquinolin-2(1H)-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Luo L, et al. Nat Chem Biol. 2007 Nov;3(11):722-6.
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