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TCS-OX2-29

CAS No. 372523-75-6

TCS-OX2-29( —— )

Catalog No. M19326 CAS No. 372523-75-6

TCS-OX2-29 is a potent and selective OX2 receptor antagonist (IC50: 40 nM). It displays >250-fold selectivity for OX2 over OX1.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    TCS-OX2-29
  • Note
    Research use only, not for human use.
  • Brief Description
    TCS-OX2-29 is a potent and selective OX2 receptor antagonist (IC50: 40 nM). It displays >250-fold selectivity for OX2 over OX1.
  • Description
    TCS-OX2-29 is a potent and selective OX2 receptor antagonist (IC50: 40 nM). It displays >250-fold selectivity for OX2 over OX1.
  • In Vitro
    TCS-OX2-29 inhibits orexin A induced IP3 accumulation and ERK1/2 phosphorylation in CHO cells transfected with the OX2 receptor.
  • In Vivo
    TCS-OX2-29 (5-10 mg/kg; intraperitoneal injection; adult male NMRI mice) treatment suppresses conditioned place preference (CPP) acquisition and expression in both na?ve and dependent mice significantly. Animal Model:440 adult male NMRI mice (25-30 g)Dosage:5 mg/kg and 10 mg/kg Administration:Intraperitoneal injection (Pharmacokinetic study) Result:Suppressed conditioned place preference (CPP) acquisition and expression in both na?ve and dependent mice significantly.
  • Synonyms
    ——
  • Pathway
    Cytoskeleton/Cell Adhesion Molecules
  • Target
    Kinesin
  • Recptor
    OX2
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    372523-75-6
  • Formula Weight
    397.51
  • Molecular Formula
    C23H31N3O3
  • Purity
    >98% (HPLC)
  • Solubility
    H2O : < 0.1 mg/mL
  • SMILES
    COC1=C(OC)C=C2CN(CCC2=C1)C(=O)[C@@H](NCC1=CC=NC=C1)C(C)(C)C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Hirose M et al. N-acyl 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline: the first orexin-2 receptor selective non-peptidicantagonist. Bioorg Med Chem Lett, 2003 Dec 15, 13(24):4497-9.
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