Cart
sales@molnova.com
Home - Products - Cytoskeleton/Cell Adhesion Molecules - HSP - KRIBB11

KRIBB11

CAS No. 342639-96-7

KRIBB11( KRIBB-11 | KRIBB 11 )

Catalog No. M14166 CAS No. 342639-96-7

KRIBB11 is a small molecule heat shock factor 1 (HSF1) inhibitor with IC50 of 1.2 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 42 In Stock
10MG 63 In Stock
25MG 146 In Stock
50MG 248 In Stock
100MG 483 In Stock
200MG 680 In Stock
500MG 1035 In Stock
1G Get Quote In Stock
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    KRIBB11
  • Note
    Research use only, not for human use.
  • Brief Description
    KRIBB11 is a small molecule heat shock factor 1 (HSF1) inhibitor with IC50 of 1.2 uM.
  • Description
    KRIBB11 is a small molecule heat shock factor 1 (HSF1) inhibitor with IC50 of 1.2 uM; inhibits HSF1 downstream target proteins HSP70 and HSP72 synthesis, induces growth arrest and apoptosis in HCT-116 cells, inhibits HSF1-dependent recruitment of p-TEFb to the hsp70 promoter; inhibits tumor growth without body weight loss in mice model.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    KRIBB-11 | KRIBB 11
  • Pathway
    Cytoskeleton/Cell Adhesion Molecules
  • Target
    HSP
  • Recptor
    HSF1
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    342639-96-7
  • Formula Weight
    284.27338
  • Molecular Formula
    C13H12N6O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 27 mg/mL
  • SMILES
    O=[N+](C1=CC=C(NC)N=C1NC2=CC3=C(NN=C3)C=C2)[O-]
  • Chemical Name
    2,6-Pyridinediamine, N2-1H-indazol-5-yl-N6-methyl-3-nitro-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Yoon YJ, et al. J Biol Chem. 2011 Jan 21;286(3):1737-47. 2. Kang MJ, et al. Biochem Biophys Res Commun. 2017 Oct 21;492(3):304-309. 3. Carpenter RL, et al. Oncotarget. 2017 May 22;8(43):73947-73963. 4. Samarasinghe B, et al. Biochem Pharmacol. 2014 Feb 1;87(3):445-55.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • PU-H71

    PU-H71 is a potent and selective inhibitor of HSP90 with IC50 of 51 nM. Phase 1.

  • PU-WS13

    A potent and selective Grp94 inhibitor with Ic50 of 0.22 uM.

  • YM-1

    YM-1 is a close derivative of MTK-077 that allosterically promotes Hsp70 binding to unfolded substrates, specificly binds to Hsp70 with Kd of 4.9 uM.

Sign In Join Free