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Home - Products - Cytoskeleton/Cell Adhesion Molecules - HSP - YM-1

YM-1

CAS No. 409086-68-6

YM-1( YM1 )

Catalog No. M14406 CAS No. 409086-68-6

YM-1 is a close derivative of MTK-077 that allosterically promotes Hsp70 binding to unfolded substrates, specificly binds to Hsp70 with Kd of 4.9 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    YM-1
  • Note
    Research use only, not for human use.
  • Brief Description
    YM-1 is a close derivative of MTK-077 that allosterically promotes Hsp70 binding to unfolded substrates, specificly binds to Hsp70 with Kd of 4.9 uM.
  • Description
    YM-1 is a close derivative of MTK-077 that allosterically promotes Hsp70 binding to unfolded substrates, specificly binds to Hsp70 with Kd of 4.9 uM; enhances client protein ubiquitination and polyQ AR degradation; alleviates toxicity in a Drosophila model of spinobulbar muscular atrophy (SBMA); also disrupts the Hsp70-Bag3 interaction with IC50 of 5 uM.
  • In Vitro
    Western Blot Analysis Cell Line:HeLa and hTERT-RPE1 cell lines Concentration:10 μM Incubation Time:48 hoursI Result:Increased the level of p53 and p21 and decreased the level of FoxM1 and survivin.
  • In Vivo
    Animal Model:UAS-hAR52Q flies with polyQ AR-induced dihydrotestosterone (DHT) phenotypeDosage:1 mM Administration:Oral administration; 1 mM, for 7 days Result:Weakened the DHT-dependent eye degeneration phenotype and rescued DHT-dependent pupal toxicity of the polyQ AR.
  • Synonyms
    YM1
  • Pathway
    Cytoskeleton/Cell Adhesion Molecules
  • Target
    HSP
  • Recptor
    HSP
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    409086-68-6
  • Formula Weight
    417.97
  • Molecular Formula
    C20H20ClN3OS2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?H2O : 50 mg/mL (119.62 mM)
  • SMILES
    CCN1C(=CC2=CC=CC=[N+]2C)SC(=C3N(C4=CC=CC=C4S3)C)C1=O.[Cl-]
  • Chemical Name
    2-((Z)-((E)-3-Ethyl-5-(3-methylbenzo[d]thiazol-2(3H)-ylidene)-4-oxothiazolidin-2-ylidene)methyl)-1-methylpyridin-1-ium chloride

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Wang AM, et al. Nat Chem Biol. 2013 Feb;9(2):112-8. 2. Morishima Y, et al. Biochemistry. 2011 Aug 23;50(33):7146-56. 3. Colvin TA, et al. Cancer Res. 2014 Sep 1;74(17):4731-40.
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