GW406108X

Research use only, not for human use.

GW406108X (GW-406108X, GW108X) is specific inhibitor of Kif15 (Kinesin-12) with IC50 of 0.82 uM in ATPase assays.

GW406108X (GW-406108X, GW108X) is specific inhibitor of Kif15 (Kinesin-12) with IC50 of 0.82 uM in ATPase assays; GW108X displays a preference for Kif15 over the other mitotic motors, with 30 μM of GW108X inhibiting Kif15 MT gliding by 98.9% ± 0.2% while only inhibiting Eg5 by 19.8% ± 4.3%, HSET by 5.3% ± 2.9% and Kif18A by 4.9%; inhibits the MT-stimulated ATPase and MT gliding activity of Kif15 either by inhibiting ATP binding or by inhibiting MT binding by the motorl; shows a distinct mechanism of action compared with the Kif15 inhibitor, Kif15-IN-1.

GW-406108X;GW108X

Cytoskeleton/Cell Adhesion Molecules

Kinesin

Kinesin

——

——

1644443-92-4

400.21

C20H11Cl2NO4

>98% (HPLC)

——

C1=COC(=C1)C(=O)C2=CC3=C(C=C2)NC(=O)C3=CC4=CC(=C(C(=C4)Cl)O)Cl

(Z)-3-(3,5-dichloro-4-hydroxybenzylidene)-5-(furan-2-carbonyl)indolin-2-one

(-20℃)

With Ice Pack

≥ 2 years