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MK-8267

CAS No. 1146209-50-8

MK-8267( SCH 2047069 )

Catalog No. M10516 CAS No. 1146209-50-8

MK-8267 (SCH 2047069) is a potent, orally bioavailable, brain penetrant kinesin spindle protein (KSP) inhibitor with EC50 of 3 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    MK-8267
  • Note
    Research use only, not for human use.
  • Brief Description
    MK-8267 (SCH 2047069) is a potent, orally bioavailable, brain penetrant kinesin spindle protein (KSP) inhibitor with EC50 of 3 nM.
  • Description
    MK-8267 (SCH 2047069) is a potent, orally bioavailable, brain penetrant kinesin spindle protein (KSP) inhibitor with EC50 of 3 nM; inhibits a broader panel of 57 different tumor cell lines with IC50 <30 nM; showes significant brain uptake in mouse and rat with brain/plasma AUC ratio of 4 in rats, demonstrates anti-tumor activities in the tumor xenograft mouse model.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    SCH 2047069
  • Pathway
    Cytoskeleton/Cell Adhesion Molecules
  • Target
    Kinesin
  • Recptor
    Kinesin
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1146209-50-8
  • Formula Weight
    439.429
  • Molecular Formula
    C20H17F4N3O2S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    1-(3-(2-Aminoethyl)-5'-(2,5-difluorophenyl)-6,7-difluoro-3'H-spiro[chromane-4,2'-[1,3,4]thiadiazol]-3'-yl)ethan-1-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Mansoor UF, et al. Bioorg Med Chem. 2015 May 15;23(10):2424-34.
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