Dolutegravir

CAS No. 1051375-16-6

Dolutegravir ( GSK1349572;GSK-1349572;GSK 1349572 )

Catalog No. M10248 CAS No. 1051375-16-6

Dolutegravir (GSK1349572) is a potent, next-generation HIV integrase (IN) inhibitor, inhibits HIV-1 integrase-catalyzed strand transfer with IC50 of 2.7 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 39 In Stock
5MG 61 In Stock
10MG 105 In Stock
25MG 162 In Stock
50MG 259 In Stock
100MG 405 In Stock
200MG 574 In Stock
500MG 806 In Stock
1G 1053 In Stock

Biological Information

  • Product Name
    Dolutegravir
  • Note
    Research use only, not for human use.
  • Brief Description
    Dolutegravir (GSK1349572) is a potent, next-generation HIV integrase (IN) inhibitor, inhibits HIV-1 integrase-catalyzed strand transfer with IC50 of 2.7 nM.
  • Description
    Dolutegravir (GSK1349572) is a potent, next-generation HIV integrase (IN) inhibitor, inhibits HIV-1 integrase-catalyzed strand transfer with IC50 of 2.7 nM; inhibits HIV-1 replication in PBMCs, MT-4 cells and in the PHIV assay with EC50 of 0.51, 0.71 and 2.2 nM, respectively; demonstrates activity against site-directed molecular clones containing the raltegravir-resistant signature mutations Y143R, Q148K, N155H, and G140S/Q148H; exhibits excellent anti-HIV activity in combination with representative approved antiretroviral agents in vivo.HIV Infection Approved
  • Synonyms
    GSK1349572;GSK-1349572;GSK 1349572
  • Pathway
    Microbiology/Virology
  • Target
    HIV
  • Recptor
    HIVintegrase
  • Research Area
    Infection
  • Indication
    HIV Infection

Chemical Information

  • CAS Number
    1051375-16-6
  • Formula Weight
    419.38
  • Molecular Formula
    C20H19F2N3O5
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 10 mg/mL
  • SMILES
    [H][C@]12CN3C=C(C(=O)NCC4=C(F)C=C(F)C=C4)C(=O)C(O)=C3C(=O)N1[C@H](C)CCO2 |r,c:10,16,22,t:4,13|
  • Chemical Name
    2H-Pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, N-[(2,4-difluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-, (4R,12aS)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Kobayashi M, et al. Antimicrob Agents Chemother. 2011 Feb;55(2):813-21.
2. Garrido C, et al. Antiviral Res. 2011 Jun;90(3):164-7.
3. Hightower KE, et al. Antimicrob Agents Chemother. 2011 Oct;55(10):4552-9.
4. Hare S, et al. Mol Pharmacol. 2011 Oct;80(4):565-72.
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