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Dolutegravir
CAS No. 1051375-16-6
Dolutegravir ( GSK1349572;GSK-1349572;GSK 1349572 )
Catalog No. M10248 CAS No. 1051375-16-6
Dolutegravir (GSK1349572) is a potent, next-generation HIV integrase (IN) inhibitor, inhibits HIV-1 integrase-catalyzed strand transfer with IC50 of 2.7 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 39 | In Stock |
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| 5MG | 61 | In Stock |
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| 10MG | 105 | In Stock |
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| 25MG | 162 | In Stock |
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| 50MG | 259 | In Stock |
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| 100MG | 405 | In Stock |
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| 200MG | 574 | In Stock |
|
| 500MG | 806 | In Stock |
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| 1G | 1053 | In Stock |
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Biological Information
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Product NameDolutegravir
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NoteResearch use only, not for human use.
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Brief DescriptionDolutegravir (GSK1349572) is a potent, next-generation HIV integrase (IN) inhibitor, inhibits HIV-1 integrase-catalyzed strand transfer with IC50 of 2.7 nM.
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DescriptionDolutegravir (GSK1349572) is a potent, next-generation HIV integrase (IN) inhibitor, inhibits HIV-1 integrase-catalyzed strand transfer with IC50 of 2.7 nM; inhibits HIV-1 replication in PBMCs, MT-4 cells and in the PHIV assay with EC50 of 0.51, 0.71 and 2.2 nM, respectively; demonstrates activity against site-directed molecular clones containing the raltegravir-resistant signature mutations Y143R, Q148K, N155H, and G140S/Q148H; exhibits excellent anti-HIV activity in combination with representative approved antiretroviral agents in vivo.HIV Infection Approved
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SynonymsGSK1349572;GSK-1349572;GSK 1349572
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PathwayMicrobiology/Virology
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TargetHIV
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RecptorHIVintegrase
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Research AreaInfection
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IndicationHIV Infection
Chemical Information
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CAS Number1051375-16-6
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Formula Weight419.38
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Molecular FormulaC20H19F2N3O5
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Purity>98% (HPLC)
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SolubilityDMSO: 10 mg/mL
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SMILES[H][C@]12CN3C=C(C(=O)NCC4=C(F)C=C(F)C=C4)C(=O)C(O)=C3C(=O)N1[C@H](C)CCO2 |r,c:10,16,22,t:4,13|
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Chemical Name2H-Pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, N-[(2,4-difluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-, (4R,12aS)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Kobayashi M, et al. Antimicrob Agents Chemother. 2011 Feb;55(2):813-21.
2. Garrido C, et al. Antiviral Res. 2011 Jun;90(3):164-7.
3. Hightower KE, et al. Antimicrob Agents Chemother. 2011 Oct;55(10):4552-9.
4. Hare S, et al. Mol Pharmacol. 2011 Oct;80(4):565-72.
2. Garrido C, et al. Antiviral Res. 2011 Jun;90(3):164-7.
3. Hightower KE, et al. Antimicrob Agents Chemother. 2011 Oct;55(10):4552-9.
4. Hare S, et al. Mol Pharmacol. 2011 Oct;80(4):565-72.
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