ABX464

Research use only, not for human use.

ABX464 (ABX-464, ABX 464) is a novel class of anti-HIV small molecule targeting Rev-mediated viral RNA biogenesis.

ABX464 (ABX-464, ABX 464) is a novel class of anti-HIV small molecule targeting Rev-mediated viral RNA biogenesis, shows dose dependent inhibition of HIV-1 replication in stimulated PBMCs with IC50 of 0.1-0.5 uM; ABX464 inhibits different HIV-1 clades, resistant viruses and did not select for resistance; increases the levels of spliced HIV RNA, influences REV-mediated HIV RNA biogenesis and export, and interacts with the CBC complex; inhibit viral replication in humanized mice.HIV Infection Phase 2 Clinical

ABX-464;ABX 464

Microbiology/Virology

HIV

HIV

Infection

HIV Infection

1258453-75-6

338.71

C16H10ClF3N2O

>98% (HPLC)

DMSO : ≥ 100 mg/mL 295.24 mM

FC(F)(F)OC1=CC=C(NC2=NC3=C(Cl)C=CC=C3C=C2)C=C1

8-chloro-N-(4-(trifluoromethoxy)phenyl)quinolin-2-amine

(-20℃)

With Ice Pack

≥ 2 years