DRB

Research use only, not for human use.

DRB is a nucleoside analog that inhibits several carboxyl-terminal domain (CTD) kinases including casein kinase II (IC50 range of 4-10 μM).

DRB is a nucleoside analog that inhibits several carboxyl-terminal domain (CTD) kinases including casein kinase II (IC50 range of 4-10 μM).

Western Blot Analysis Cell Line:LS174T, HT29, SW48 Concentration:80 μg/mL Incubation Time:24 h Result:Decreased incorporation of [5,6-3H] uridine and increased level of p53 protein.Cell Viability Assay Cell Line:MCF-7, T-47D Concentration:10, 50, 75,100 μM Incubation Time:72 h Result:Inhibited cell-growth in a dose-dependent manner.Resulted in a higher early apoptotic population (5.7 ± 1.1 vs. 2 ± 0.4%) and late apoptotic population (15.9 ± 2.4 vs. 7.7 ± 0.9%) at a concentration of 75 μM.Western Blot Analysis Cell Line:MCF-7 Concentration:75 μM Incubation Time:0.5, 2, 6, 10 h Result:Reduced Mcl-1 protein levels in a time-dependent manner and increased the level of p53 after 6 h.

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Microbiology/Virology

HIV

HIV

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53-85-0

319.14

C12H12Cl2N2O4

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (313.34 mM)

OC[C@H]1O[C@@H](n2cnc3cc(Cl)c(Cl)cc32)[C@H](O)[C@@H]1O

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(-20℃)

With Ice Pack

≥ 2 years